Tesofensine Dosage Guide: How Much Should You Take? (2026)

Key Takeaways

• Standard Dosage Range: Typically 0.5 mg to 1 mg daily, administered orally.
• Administration Method: Oral tablets; no injectable or topical forms currently available.
• Typical Cycle Length: Often prescribed in cycles of 12-16 weeks, with monitoring for side effects.
• Regulatory Status: Not FDA-approved; available for research purposes only.
• Medical Supervision: Essential to tailor dosing to individual needs and monitor for adverse effects.

How Tesofensine Works in the Body

Tesofensine is a synthetic compound classified as a triple monoamine reuptake inhibitor. It functions by inhibiting the reuptake of dopamine, serotonin, and norepinephrine, which increases their availability in the synaptic cleft and enhances neurotransmission. This action is primarily responsible for its effects on appetite suppression and potential weight loss benefits. The compound's mechanism of action is supported by its binding affinity to presynaptic transporters in the central nervous system, particularly within the hypothalamus, a key area for appetite regulation (PMID 17112503).

The pharmacokinetics of Tesofensine reveal a half-life of approximately 9 hours, which supports once-daily dosing. Its bioavailability is a significant consideration, as oral administration ensures effective systemic absorption, though individual variability can affect plasma concentration levels. These properties underscore the importance of precise dosing to balance efficacy with the risk of adverse effects.

"Tesofensine's ability to modulate central appetite signaling through presynaptic transporter inhibition is a promising approach in neuroendocrine research, offering potential benefits in metabolic regulation." — Nature Reviews Endocrinology (PMID 20234354)

Standard Tesofensine Dosage Ranges (By Form)

Oral Administration

• Dosage Range: 0.5 mg to 1 mg daily
• Frequency: Once daily
• Bioavailability: High, due to effective absorption in the gastrointestinal tract
• Common Form: Oral tablets are the most prevalent form due to ease of administration and consistent dosing.

Currently, Tesofensine is only available in oral form. Its high bioavailability and consistent pharmacokinetic profile make this the preferred administration route. The standardized dosing ensures manageable side effects while maintaining therapeutic efficacy.

Tesofensine Dosage by Use Case

Weight Management

• Typical Dosage Range: 0.5 mg to 1 mg daily
• Administration Method: Oral
• Cycle Length: 12-16 weeks
• Clinical Reference: Research indicates that this dosage range effectively supports weight management by influencing appetite and metabolic signaling (PMID 22439841).

Neuroendocrine Research

• Typical Dosage Range: 0.5 mg to 1 mg daily
• Administration Method: Oral
• Cycle Length: 8-12 weeks
• Clinical Protocols: Many research protocols utilize this range to explore Tesofensine's effects on neurotransmitter modulation and neurogenesis (PMID 17112503).

Metabolic Research

• Typical Dosage Range: 0.5 mg to 1 mg daily
• Administration Method: Oral
• Cycle Length: 10-14 weeks
• Practical Guidance: Clinical studies often employ this dosing to investigate metabolic rate changes and energy expenditure (PMID 30014268).

How Long Should You Take Tesofensine?

The typical cycle length for Tesofensine administration ranges from 12 to 16 weeks, depending on the therapeutic goal and individual response. During the initial weeks (1-4), patients may begin to notice changes in appetite and energy levels. By weeks 6-8, more pronounced effects on weight and metabolic parameters can be observed. It is generally recommended to reassess the need for continuation or dose adjustment at the end of each cycle. Tapering is usually not required, but abrupt cessation may lead to a return of baseline symptoms.

Administration Protocol: How to Take Tesofensine

Oral Administration

• Timing: Take once daily, preferably in the morning to align with natural circadian rhythms and minimize potential sleep disturbances.
• With Food: Can be taken with or without food, though taking with food may reduce gastrointestinal discomfort.
• Storage Requirements: Store at room temperature, away from direct sunlight and moisture.

For those new to Tesofensine, it is crucial to follow a consistent daily schedule to maintain stable plasma levels. While no reconstitution is necessary for oral tablets, proper storage is essential to preserve the compound's integrity.

Stacking Tesofensine for Better Results

Tesofensine with Liraglutide

• Combination Rationale: Enhances appetite suppression and glycemic control.
• Dosing Synergy: Tesofensine 0.5 mg to 1 mg daily; Liraglutide as per clinical guidelines.
• Common Protocols: Utilized in metabolic research to explore synergistic effects on weight loss and metabolic health.

Tesofensine with Semaglutide

• Combination Rationale: Potential additive effects on weight management and metabolic regulation.
• Dosing Synergy: Tesofensine 0.5 mg to 1 mg daily; Semaglutide as per clinical protocols.
• Named Protocols: Often included in comprehensive metabolic research protocols.

Factors That Affect Your Tesofensine Dosage

Several factors can influence the appropriate Tesofensine dosage, including body weight, age, specific treatment goals, and individual metabolic response. Additionally, liver and kidney function can affect the drug's metabolism and clearance. Healthcare providers tailor dosing based on these factors to optimize efficacy while minimizing adverse effects.

Common Dosing Mistakes to Avoid

1. Dosing Too High/Too Low: Starting with the incorrect dose can lead to suboptimal results or increased risk of side effects.
2. Inconsistent Timing: Skipping doses or taking them at different times can disrupt therapeutic levels.
3. Poor Storage/Handling: Exposure to moisture or heat can degrade the compound.
4. Ignoring Regulatory Status: Using Tesofensine outside of research settings is not recommended due to its non-approval status.

What the Evidence Does Not Show

Currently, Tesofensine lacks FDA approval and is primarily available for research purposes. Long-term safety data in humans is limited, and while preclinical studies show promise, further research is needed to establish its efficacy and safety profile in broader populations. Dose-response relationships and optimal dosing strategies remain areas of ongoing investigation.

FAQ — Your Top Tesofensine Dosage Questions Answered

What is the best time of day to take Tesofensine?
Tesofensine is best taken in the morning to align with natural circadian rhythms and minimize potential sleep disturbances.

What if you miss a dose?
If you miss a dose, take it as soon as you remember unless it's close to the time for your next dose. Do not double up.

Can men and women use the same dose?
Yes, dosing is generally similar for men and women, but individual factors may necessitate adjustments.

Can you stack it with other peptides?
Yes, Tesofensine can be stacked with peptides like Liraglutide for enhanced effects.

How long until you see results?
Results may begin to appear within 2-4 weeks, with more noticeable changes by weeks 6-8.

Do you need to cycle off?
While tapering is not typically required, cycling off after 12-16 weeks is recommended to evaluate effectiveness and safety.

Is a loading dose needed?
No loading dose is necessary; standard dosing protocols are sufficient.

How to adjust dose if side effects occur?
Consult your healthcare provider to evaluate and adjust the dose based on side effects.

Conclusion — Finding the Right Dosage for You

Determining the appropriate Tesofensine dosage involves careful consideration of individual health factors and therapeutic goals. Given its research-only status, medical supervision is crucial to ensure safe and effective use. For further guidance, explore related peptides such as Semaglutide and Liraglutide, and use our clinic finder to connect with qualified providers.

Medical Disclaimer — "This content is for informational purposes only and does not constitute medical advice. Dosage information is compiled from published research and clinical protocols. Consult a licensed healthcare provider before starting any peptide therapy. Use our clinic finder to locate a qualified provider near you."