


Evolve Health operates as a primary care and hormone therapy clinic in Honolulu, Hawaii, serving patients who require comprehensive medical management alongside specialized endocrine interventions. The practice maintains ANCC Board Certification and structures its services around three clinical pillars: primary care medicine, lifestyle-based chronic disease management, and gender-affirming hormone therapy. Patients access the clinic for both routine health maintenance and complex hormonal protocols that require ongoing monitoring and dose adjustments based on laboratory results and symptom tracking.
The hormone therapy programs at Evolve Health address both gender-affirming care and age-related hormonal optimization. For transgender and non-binary patients, the clinic prescribes and monitors estradiol, testosterone cypionate, progesterone, and anti-androgen medications according to WPATH Standards of Care guidelines, with regular follow-up appointments to assess physical changes, emotional well-being, and metabolic markers. The lifestyle medicine component integrates nutritional counseling, exercise prescription, and stress management techniques to support patients managing hypertension, prediabetes, metabolic syndrome, and obesity. This dual focus allows the Honolulu practice to address both acute hormonal needs and long-term preventive health strategies within a single care relationship.
The clinical team at Evolve Health includes ANCC-certified providers who conduct comprehensive intake assessments that cover medical history, current medications, mental health status, and specific treatment goals. New patients undergoing hormone therapy receive baseline laboratory panels measuring liver function, lipid profiles, hemoglobin, and hormone levels before initiating treatment. Follow-up visits occur at three-month intervals during the first year, then extend to six-month check-ins for stable patients. The practice emphasizes patient education, providing written materials on injection techniques for self-administered testosterone, expected timelines for physical changes on estrogen therapy, and warning signs that require immediate clinical contact.
Patients in Honolulu report that the front desk staff at Evolve Health facilitate appointment scheduling and insurance verification efficiently, while clinical visits allow adequate time for questions about treatment protocols and side effect management. The practice accepts most major insurance plans for primary care visits and works with patients to determine coverage for hormone therapy services, which varies significantly by insurer and policy type. For patients requiring prior authorizations for specific medications or laboratory tests, the clinic submits necessary documentation and follows up with insurance companies to expedite approval processes.
Evolve Health differentiates itself in the Honolulu medical community by combining primary care accessibility with specialized hormone management, eliminating the need for patients to maintain separate relationships with a family medicine provider and an endocrinologist or gender specialist. The practice schedules same-day appointments for urgent concerns and offers telehealth consultations for established patients who need prescription refills, lab result reviews, or clinical guidance between in-person visits. This integrated model proves particularly valuable for patients managing multiple chronic conditions alongside hormone therapy, as the clinical team maintains a complete view of medication interactions, cumulative health risks, and treatment priorities across all body systems.
Nicole Ryan, DNP, APRN, FNP-BC
Founder & Medical Director
Nicole Ryan is an ANCC board certified Family Nurse Practitioner who earned her Doctor of Nursing (DNP) degree from the University of Hawaii at Manoa. Her clinical interests and specialties include primary care and lifestyle medicine, integrative nutrition and gut health, hormone therapy, and gender-affirming care.
Sheeren Liao Masifi, MD
Primary Care and HRT Provider
Sheeren Liao Masifi is originally from Syracuse, NY, but has lived mostly in San Diego, CA since 2001. She obtained her BS at the University of California, San Diego, and went on to receive her MD at the Drexel University College of Medicine, completing her training in Family Medicine.
Topics Mentioned in Reviews
Direct Primary Care/ Lifestyle Medicine
Combining primary care and lifestyle medicine principles to create an accessible and innovative patient care model.
Nutrition Counseling
A program that provides support and resources to feel better, increase energy, and reduce pain.
Hormone Therapy
Includes gender-affirming hormone therapy, hormone therapy for menopause, and testosterone replacement therapy.
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