


Zero Gravity Medical in Knoxville, Tennessee, provides integrative medical services with a focus on hormone optimization, metabolic health, and preventive care under the clinical direction of Matthew Cantrell, PA-C. The clinic combines evidence-based hormone replacement therapy with advanced weight management protocols, cancer screening programs, aesthetic treatments, and urgent care services, creating a comprehensive approach to wellness that addresses both immediate health concerns and long-term optimization goals. Patients in the Knoxville area benefit from a clinic model that integrates multiple specialties under one roof, allowing for coordinated care that considers the interconnected nature of hormonal balance, metabolic function, and overall vitality.
The weight management program at Zero Gravity Medical centers on GLP-1 receptor agonist therapy using Semaglutide and Tirzepatide, two peptide medications that work by mimicking incretin hormones to regulate appetite, slow gastric emptying, and improve insulin sensitivity. Semaglutide, originally developed for type 2 diabetes management and now FDA-approved for chronic weight management, has demonstrated average weight loss of 12-15% of body weight in clinical trials when combined with lifestyle modifications. Tirzepatide represents a dual GIP/GLP-1 receptor agonist with enhanced metabolic effects, showing even greater weight reduction potential in recent studies. Matthew Cantrell tailors dosing protocols based on individual patient response, metabolic markers, and tolerance profiles, with regular monitoring to optimize outcomes and minimize side effects such as nausea or gastrointestinal discomfort that can occur during dose escalation phases.
Matthew Cantrell, PA-C, brings physician assistant training and clinical experience to his practice at Zero Gravity Medical, working collaboratively with patients to develop treatment plans that address root causes rather than simply managing symptoms. His approach to hormone replacement therapy encompasses comprehensive lab evaluation including thyroid panels, sex hormones, cortisol patterns, and metabolic markers to identify deficiencies or imbalances that may contribute to fatigue, weight gain, mood changes, or decreased quality of life. The clinic's hormone optimization protocols are individualized based on patient age, symptoms, lab values, and health goals, with bioidentical hormone options available for both men and women experiencing age-related hormonal decline or specific endocrine conditions. Cantrell's practice philosophy emphasizes patient education, ensuring individuals understand the mechanisms behind their treatments and the expected timeline for clinical improvements.
Patients visiting Zero Gravity Medical in Knoxville can expect thorough initial consultations that include detailed health history review, current symptom assessment, and discussion of treatment goals before any therapy is initiated. The weight loss program typically begins with baseline metabolic labs, body composition analysis, and cardiovascular risk assessment to establish starting parameters and identify any contraindications to GLP-1 therapy. Follow-up visits are scheduled at regular intervals to monitor progress, adjust medication dosing, address any side effects, and provide ongoing nutritional guidance and lifestyle coaching that enhances peptide therapy results. The clinic's cancer screening services add an important preventive dimension, allowing patients to address early detection alongside their optimization protocols. Aesthetic treatment options provide additional support for patients seeking comprehensive wellness solutions that address both internal health markers and external appearance concerns.
Zero Gravity Medical extends access beyond traditional in-person visits by offering telehealth consultations, making hormone therapy and weight management services available to patients throughout Tennessee who may face geographic or scheduling barriers to regular clinic visits. This hybrid model allows for initial in-person evaluations when comprehensive physical assessment is beneficial, with subsequent follow-ups available via secure video platforms for medication management, lab review, and ongoing support. The clinic's urgent care capabilities provide an additional layer of convenience for established patients who develop acute health concerns while undergoing hormone or weight loss therapy, ensuring continuity of care and familiarity with patient medical history. With a perfect 5.0-star Google rating reflecting early patient satisfaction, Zero Gravity Medical positions itself as a Knoxville resource for individuals seeking medically supervised approaches to metabolic health, hormonal balance, and preventive wellness that go beyond conventional primary care models.
Matthew Cantrell· PA-C
Matthew Cantrell, PA-C
Owner/Provider
Matthew Cantrell, PA-C is a nationally certified Physician Assistant and has spent most of his adult life in medicine. He worked early on in his career as an EMT and then as a paramedic. In 2003, Matt was accepted into PA school in Southern California and upon graduation, began working in Emergency Medicine. In 2016, Matt moved to Knoxville where he continues to work as an Emergency Medicine Physician Assistant. He has trained under Master Injector, Brandy Henson, PA-C in Southern California. Matt uses his 30 years of experience years in the medical field along with his affinity for aesthetics and symmetry to help patients achieve their goals through careful listening and observation.
Whitney Cantrell
Office Manager
Whitney Cantrell manages the office at Zero Gravity Medical Aesthetics. Together, Matt and Whitney enjoy running the clinic together, traveling all over the world, and spending time with friends and family, and most importantly their little girl, Kiely.
Testosterone Replacement Therapy (TRT)
Hormone replacement therapy for men experiencing low testosterone levels.
Medical Weight Loss
Weight loss program utilizing Semaglutide and Tirzepatide injections.
Cancer Screening
Galleri® Multi-Cancer Early Detection Screening.
Botox/Xeomin Injectables
Neurotoxin injections to reduce the appearance of wrinkles.
Urgent/Primary Care
Limited urgent care and primary care visits for various conditions.
MyPeptideMatch.com is an independent directory. We do not provide medical advice. Always consult a qualified healthcare provider before starting any peptide therapy.


