Overview
Kisspeptin-10 is a neuropeptide that regulates gonadotropin-releasing hormone (GnRH) and thus reproductive hormones. It has been studied in reproductive endocrinology for fertility, libido, and hormonal regulation. Evidence in humans is moderate in that setting. In the US, kisspeptin-10 is prohibited for compounding—it is specifically listed with no approved pathway. So despite scientific interest and overseas research, it is not a legal option for human use through US compounding. People interested in sexual wellness or fertility should work with providers who use FDA-approved or legally compoundable options (e.g., PT-141/Vyleesi for HSDD where appropriate).
How It Works (Mechanism of Action)
Kisspeptin-10 binds to kisspeptin receptors and stimulates GnRH release, which in turn drives LH and FSH and thus sex hormone production. It is a key regulator of the reproductive axis.
Primary Uses
Reproductive hormone regulation, libido, fertility. Prohibited for compounding in the US. Evidence moderate in reproductive endocrinology.
FDA & Regulatory Status
Prohibited for compounding. Specifically listed.

