Semaglutide vs. tirzepatide (often searched as Ozempic vs. Mounjaro or Wegovy vs. Zepbound) is one of the most common questions in weight loss and diabetes care. Both are injectable GLP-1–based therapies with strong evidence. Here we compare mechanism, weight loss, side effects, cost, and how to choose—and point you to our full comparison page and peptide pages (tirzepatide) for detail.
Semaglutide is a GLP-1 receptor agonist—it mimics one gut hormone to reduce appetite and improve blood sugar. Tirzepatide is a dual GIP/GLP-1 agonist, so it activates both receptors. The extra GIP activity is thought to explain tirzepatide’s slightly higher average weight loss in trials. Both are given once weekly by injection (semaglutide also has a daily oral form, Rybelsus).
In head-to-head and placebo-controlled trials, tirzepatide typically produces a few percentage points more body weight loss on average (e.g., 15–20% vs. around 15% with semaglutide over similar timeframes). Both are among the most effective anti-obesity medications available. Individual response varies; many people do very well on either.
Side effect profiles are similar: nausea, diarrhea, vomiting, constipation, abdominal pain. Both are usually well tolerated with gradual dose escalation. Some patients find one drug easier than the other; there’s no universal rule. Thyroid and pancreatitis precautions apply to both.
List prices are in a similar range ($900–$1,400+ per month without insurance). Coverage for diabetes and obesity has improved for both; compounding is now restricted under FDA guidance. Your insurance formulary and copay often determine which one is more affordable. Check your plan and use manufacturer programs / Zepbound when applicable.
Choose tirzepatide if you’re aiming for maximum weight loss and it’s covered and available. Choose semaglutide if you prefer a long track record, once-weekly or oral dosing, or if tirzepatide isn’t covered. Your provider can help you decide based on your goals, comorbidities, and access. Use our clinic directory to find a provider that offers semaglutide or tirzepatide near you.
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MyPeptideMatch.com does not provide medical advice. Always consult a qualified healthcare provider before starting any peptide therapy. Regulatory status may change.
GuidesPeptide therapy for weight loss: how GLP-1 drugs work, clinical results, who qualifies, finding a provider, cost, and timeline. Your complete guide.
Peptide ScienceExplore how semaglutide functions as a GLP-1 receptor agonist to manage type 2 diabetes and aid in weight loss, along with its potential side effects like pancreatitis.
Peptide ScienceExplore the side effects of tirzepatide, an FDA-approved peptide for weight loss and type 2 diabetes, including common and serious risks.
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