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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

GHRP-2 Dosing Protocol: 5 mg Vial — Daily Dosing Schedule & Supplies

Complete GHRP-2 dosing guide using the 5 mg vial — a potent ghrelin receptor agonist for maximal GH stimulation.

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Quickstart highlights

GHRP-2 (Pralmorelin, KP-102) is a synthetic hexapeptide ghrelin receptor agonist that produces dose-dependent GH release.

  • Concentration: 2 mg/mL (5 mg vial + 2.5 mL bacteriostatic water).
  • At 2 mg/mL: 100 µg = 5 units, 200 µg = 10 units, 300 µg = 15 units.
  • GHRP-2 elevates cortisol ~30–50% at 200 µg — the most potent GHRP but not cortisol-neutral like ipamorelin.
  • Inject strictly fasted (2+ hours post-meal); space 3+ hours between doses.
  • Combine with CJC-1295 or sermorelin for synergistic GH release.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-410051–3x daily (fasted)100 µg — 5 units; conservative start to assess cortisol tolerance; 50 doses per vial
5-12200102–3x daily (fasted)200 µg — 10 units; standard therapeutic dose; 25 doses per vial
13+300152–3x daily (fasted)300 µg — 15 units; maximum recommended dose; ~17 doses per vial

Reconstitution steps

  1. Draw 2.5 mL bacteriostatic water; inject slowly down the vial wall.
  2. Swirl gently until powder dissolves; do not shake.
  3. Final concentration: 2 mg/mL. At 2 mg/mL: 1 unit = 20 µg.
  4. Label with date; refrigerate at 2–8 °C. Use within 28 days.

Supplies needed

4-week plan

  • 1 vial
  • 28 syringes
  • 3 mL bac water
  • 28 alcohol swabs

8-week plan

  • 2 vials
  • 56 syringes
  • 5 mL bac water
  • 56 alcohol swabs

12-week plan

  • 3 vials
  • 84 syringes
  • 8 mL bac water
  • 84 alcohol swabs
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Protocol overview & cycle notes

Achieve robust GH secretion via ghrelin receptor agonism with GHRP-2, understanding that its potency comes with moderate cortisol and prolactin co-stimulation that requires monitoring and cycle management.

Cycle length: 12 weeks on.

Off-cycle: 4–6 weeks off per 12-week cycle.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted at 2 mg/mL: refrigerate 2–8 °C; use within 28 days.

Injection & tracking tips

  • GHRP-2 elevates cortisol and prolactin at doses ≥200 µg — monitor for fatigue, mood changes, or water retention as surrogate markers.
  • Inject strictly in fasted state (2+ hours post-meal); food at injection time significantly blunts GH response.
  • Space injections at least 3–4 hours apart to allow somatostatin recovery between GH pulses.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • Measure morning cortisol at baseline and after 4 weeks — GHRP-2 can elevate cortisol by 30–50% at 200 µg doses.
  • Track IGF-1 every 6 weeks.
  • Log hunger levels post-injection; GHRP-2 causes significant appetite stimulation at 200+ µg doses.
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How this works & references

GHRP-2 (Pralmorelin, KP-102) is a synthetic hexapeptide ghrelin receptor agonist that produces dose-dependent GH release. Unlike ipamorelin, GHRP-2 co-stimulates ACTH secretion, increasing plasma cortisol by approximately 30–50% at 200 µg doses (Bowers et al., 1990). Prolactin elevation of 10–30% is also observed. Despite this, GHRP-2 produces the highest GH pulse amplitudes among commonly used GHRPs, making it preferred for body composition protocols where maximum GH output is prioritized over cortisol neutrality.

Sources

Frequently asked questions

Is GHRP-2 stronger than ipamorelin?
GHRP-2 produces higher peak GH pulse amplitudes than ipamorelin at equivalent doses, but the difference diminishes when either is combined with a GHRH analogue (CJC-1295 or sermorelin). Ipamorelin is preferred when cortisol neutrality is important; GHRP-2 is preferred when maximal GH output is the primary goal.
Will GHRP-2 make me hungry?
Yes — GHRP-2 stimulates ghrelin receptor-mediated appetite, which is more pronounced than with ipamorelin but less than with GHRP-6. Expect increased hunger for 30–60 minutes post-injection. Injecting before planned meals can make this a feature rather than a side effect.
How does cortisol elevation from GHRP-2 affect results?
Moderate cortisol elevation (30–50%) from GHRP-2 is typically transient (peak at 30–45 minutes, normalized within 2 hours). Chronic elevated cortisol from extended high-dose use can oppose GH's anabolic effects. Most protocols limit GHRP-2 to 12-week cycles with 4-week off periods to avoid HPA axis habituation.
What is the difference between GHRP-2 and GHRP-6?
GHRP-2 produces stronger cortisol elevation and stronger GH pulses than GHRP-6 at equal doses. GHRP-6 causes more pronounced hunger and gastric motility effects. GHRP-2 is generally preferred for body composition; GHRP-6 is sometimes used for appetite stimulation in underweight patients.
Can I use GHRP-2 alone without a GHRH analogue?
Yes — GHRP-2 alone stimulates meaningful GH release. However, combining with CJC-1295 No DAC or sermorelin (300 µg each) typically produces 2–4x greater GH pulse amplitudes through synergistic GHRH + GHRP receptor co-stimulation.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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