Skip to main content
MyPeptideMatch logoMyPeptideMatch
Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

Vilon Dosing Protocol: 20 mg Vial — Dipeptide Immune & Longevity Bioregulator Guide

Vilon (Lys-Glu dipeptide) Russian immune and longevity bioregulator dosing guide — the simplest Khavinson bioregulator for systemic immune normalization and longevity support.

Go to peptide profileCalculate your dose

Quickstart highlights

Vilon (Lys-Glu, KE) is the simplest member of Khavinson's bioregulator peptide family — a dipeptide derived from bone marrow and immune tissue preparations.

  • Concentration: 2 mg/mL (20 mg + 10 mL bac water).
  • At 2 mg/mL: 200 µg = 10 units daily x 10 days.
  • Anisimov et al.: Vilon increased mouse lifespan by 12–25% in longitudinal studies.
  • Smallest Khavinson bioregulator — systemic (not organ-specific) due to small size penetration.
  • Use as foundational bioregulator alongside organ-specific peptides (Cardiogen, Testagen, etc.).

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-2 (10-day course)20010Once daily200 µg — 10 units; standard 10-day course; 20 mg vial = 100 doses
Maintenance20010Every other day200 µg EOD — systemic longevity maintenance

Reconstitution steps

  1. Reconstitute in 2.5 mL bac water portions; inject slowly down vial wall.
  2. Swirl gently until dissolved. Final concentration: 2 mg/mL.
  3. Label with date; refrigerate 2–8 °C. Use within 28 days.

Supplies needed

10_day-week plan

  • 1 vial
  • 10 syringes
  • 2 mL bac water
  • 10 alcohol swabs
Need clinics? See vetted providers →

Protocol overview & cycle notes

Provide systemic immune normalization, bone marrow cell gene expression support, and broad longevity bioregulation through the simplest Khavinson dipeptide Vilon, as a foundational component of comprehensive anti-aging peptide protocols.

Off-cycle: 4–6 months between courses. Vilon is often used as the foundational bioregulator with organ-specific peptides added based on individual health priorities.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted: refrigerate 2–8 °C; use within 28 days.

Injection & tracking tips

  • Vilon can be injected at any time of day — the dipeptide acts systemically as a broad immune and longevity modulator.
  • Vilon is often used as the foundational bioregulator in Khavinson protocols alongside organ-specific bioregulators.
  • The Lys-Glu sequence is also found as a terminal sequence in several longer bioregulators, suggesting fundamental physiological importance.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • NK cell activity and CD3/CD4/CD8 T-cell ratios at baseline and 3 months.
  • Track subjective energy, immune resilience, and overall vitality (0–10) monthly.
  • Monitor hsCRP and IL-6 as inflammatory burden indicators quarterly.
Log your cycle in the calculator →

How this works & references

Vilon (Lys-Glu, KE) is the simplest member of Khavinson's bioregulator peptide family — a dipeptide derived from bone marrow and immune tissue preparations. Despite its small size, the Lys-Glu sequence has broad biological activity: (1) Immune cell gene expression normalization (T-cells, NK cells, dendritic cells); (2) Bone marrow stem cell proliferation support; (3) Broad epigenetic modulation via direct chromatin interaction. Anisimov et al. longitudinal studies showed that Vilon administration in aging mice increased lifespan by 12–25% compared to untreated controls. Its small molecular weight enables broad tissue penetration, making it a systemic bioregulator unlike the organ-specific longer peptides.

Sources

  • Source: Anisimov VN et al. — Vilon and Epithalon increase longevity in mice. Biogerontology. 2010
  • Source: Khavinson VK et al. — Geroprotective effects of short peptide bioregulators. Ann Gerontol. 2011

Frequently asked questions

What makes Vilon different from all other Khavinson bioregulators?
Vilon is a dipeptide (2 amino acids, Lys-Glu) — the shortest Khavinson bioregulator. Its small size allows unrestricted tissue penetration (no size-dependent cellular barriers), giving it systemic rather than organ-specific activity. Longer bioregulators (4-mer) are more organ-specific due to differential tissue uptake. Vilon affects immune, vascular, and bone marrow cell gene expression broadly.
How does Vilon extend lifespan in mice?
Anisimov et al. demonstrated 12–25% lifespan extension in senescence-accelerated mice with Vilon treatment. Proposed mechanisms include: immune normalization reducing infection mortality, reduction of chronic inflammatory burden (a major aging driver), and bone marrow stem cell gene normalization improving hematopoietic reserve. The molecular targets are consistent with hallmarks of aging (chronic inflammation, stem cell exhaustion, immune senescence).
Should Vilon be the first bioregulator to start with?
Khavinson and Russian practitioners often use Vilon as the foundational or first bioregulator because of its systemic immune-normalizing effects, which create a better physiological environment for subsequent organ-specific bioregulators to act. Starting with Vilon for 1–2 courses, then adding organ-specific peptides (Cardiogen, Cortagen, etc.) is a common Russian protocol progression.
Can Vilon be combined with Epithalon?
Yes — Vilon (immune/systemic normalization) + Epithalon (pineal/telomerase anti-aging) is one of the most referenced Khavinson anti-aging combinations. Anisimov's mouse studies tested this combination and found additive longevity effects. This combination represents a comprehensive approach: cellular lifespan extension (Epithalon) + systemic physiological normalization (Vilon).
Is there any risk of immune overactivation from Vilon?
Khavinson's principle of 'bioregulator normalization' implies that these peptides restore physiological balance rather than causing supraphysiological stimulation. In immunodeficient states, Vilon increases immune function; in overactive states, it may normalize downward. No cases of autoimmune exacerbation from Vilon are documented. Theoretical caution applies in active autoimmune flares.

Related protocols

Vesugen Dosing Protocol: 20 mg Vial — Vascular Bioregulator & Cardiovascular Guide

Vesugen (Lys-Glu-Asp tetrapeptide) Russian vascular bioregulator dosing guide — endothelial cell gene normalization for arterial health, blood pressure regulation, and cardiovascular aging.

View protocol

Testagen Dosing Protocol: 20 mg Vial — Testicular Bioregulator & Testosterone Support Guide

Testagen (Lys-Glu-Asp-Gly tetrapeptide) Russian testicular bioregulator dosing guide — Leydig cell gene normalization for testosterone production optimization and male reproductive aging support.

View protocol

Prostamax Dosing Protocol: 20 mg Vial — Prostate Bioregulator Guide

Prostamax (Lys-Asp-Glu-Leu tetrapeptide) Russian prostate bioregulator dosing guide — prostatic epithelial gene normalization for BPH, prostate aging, and urinary symptom support.

View protocol

Ovagen Dosing Protocol: 20 mg Vial — GI Tract Bioregulator & Gut Health Guide

Ovagen (Glu-Asp-Leu-Pro tetrapeptide) Russian gastrointestinal bioregulator dosing guide — intestinal epithelial gene normalization for gut health and digestive aging support.

View protocol

This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

Need help?

Browse vetted clinicsView full peptide profile →