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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

Selank Dosing Protocol: 5 mg Vial — Anxiolytic & Cognitive Enhancement Guide

Selank heptapeptide anxiolytic dosing guide for the 5 mg vial, based on Russian clinical data for generalized anxiety disorder and cognitive enhancement.

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Quickstart highlights

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed by the Institute of Molecular Genetics, Russian Academy of Sciences.

  • Concentration: 2 mg/mL (5 mg vial + 2.5 mL bacteriostatic water).
  • At 2 mg/mL: 250 µg = 12.5 units, 500 µg = 25 units once or twice daily.
  • Zozulya et al. 2001: 500 µg/day x 14 days produced GAD symptom reduction comparable to oxazepam without sedation.
  • One 5 mg vial provides 10 doses at 500 µg — approximately 10 days at once-daily dosing.
  • Inject in the morning for cognitive clarity and anxiety management without sedation.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-225012.5Once daily (morning)250 µg — 12.5 units; conservative start; assess anxiolytic response without sedation
3-1250025Once or twice daily500 µg — 25 units; standard therapeutic dose from Russian clinical trials; 5 mg vial provides 10 doses at this level

Reconstitution steps

  1. Draw 2.5 mL bacteriostatic water; inject slowly down the vial wall.
  2. Swirl gently until dissolved; do not shake.
  3. Final concentration: 2 mg/mL. At 2 mg/mL: 250 µg = 12.5 units, 500 µg = 25 units.
  4. Label with date; refrigerate at 2–8 °C. Use within 28 days.

Supplies needed

4-week plan

  • 1 vial
  • 28 syringes
  • 3 mL bac water
  • 28 alcohol swabs

10-week plan

  • 3 vials
  • 70 syringes
  • 8 mL bac water
  • 70 alcohol swabs
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Protocol overview & cycle notes

Reduce anxiety, normalize stress hormone response, and enhance working memory through daily Selank subcutaneous injections targeting tuftsin-mediated enkephalin stabilization and BDNF upregulation.

Cycle length: 10 weeks on.

Off-cycle: 4 weeks off after every 10-week cycle.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted at 2 mg/mL: refrigerate 2–8 °C; use within 28 days. Selank can also be administered intranasally (diluted to 0.15 mg/mL, 2 drops per nostril).

Injection & tracking tips

  • Inject subcutaneously in the morning (6–9 AM) — Selank's anxiolytic and cognitive effects are best utilized during active waking hours.
  • Selank does not cause sedation at standard doses (unlike benzodiazepines); many users report clarity of thinking and reduced rumination.
  • Intranasal route (dilute to 0.15 mg/mL, 2 drops per nostril = ~300 µg) is an alternative for faster CNS onset but requires precise dilution.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • Complete the GAD-7 Generalized Anxiety Disorder scale weekly to quantify anxiolytic response.
  • Record subjective cognitive clarity and working memory quality (0–10) daily.
  • Log sleep quality and morning cortisol-related symptoms (anxiety on waking, racing thoughts) weekly.
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How this works & references

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed by the Institute of Molecular Genetics, Russian Academy of Sciences. It is a synthetic analogue of tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro C-terminal extension. Selank stabilizes enkephalin (endogenous opioid) degradation, increases GABA-A receptor sensitivity, reduces IL-6 and other pro-inflammatory cytokines, and upregulates BDNF in the hippocampus. In Russian Phase 2 trials (Zozulya et al., 2001), Selank 500 µg daily for 14 days produced significant GAD symptom reduction comparable to oxazepam without sedation or dependence.

Sources

Frequently asked questions

How does Selank differ from benzodiazepines for anxiety?
Selank reduces anxiety through enkephalin stabilization and GABA-A modulation without causing dependence, sedation, or cognitive impairment — the primary limitations of benzodiazepines. Unlike benzodiazepines, Selank also has nootropic (cognitive-enhancing) effects, typically improving working memory and mental clarity rather than dulling them.
How long before Selank's anxiolytic effects are noticeable?
Many users report acute anxiolytic effects within 30–60 minutes of injection. Cumulative effects (BDNF upregulation, enkephalin system normalization) build over 2–4 weeks of daily use, producing more durable anxiety reduction. The Russian clinical trials used 10–14 day courses for initial assessment.
Can Selank be used alongside prescription anxiolytics?
Theoretically compatible — Selank and SSRIs/SNRIs act through different pathways (enkephalin/GABA vs. serotonin reuptake). Some practitioners use Selank as an adjunct while tapering benzodiazepines. Discuss with your prescriber; no formal interaction studies are published.
Is Selank approved anywhere?
Selank is approved as a pharmaceutical drug in Russia (nasal drops) and some CIS countries for generalized anxiety disorder. It is not approved by the FDA in the US. Available as a compounded research peptide through licensed US compounding pharmacies.
What is the difference between Selank and Semax?
Both are Russian synthetic neuropeptides with cognitive and anxiolytic properties, but their primary actions differ: Selank (ACTH analogue) primarily reduces anxiety through enkephalin stabilization; Semax (ACTH 4-7 analogue) primarily enhances cognition through BDNF upregulation and dopamine signaling. Many users find Semax more stimulating; Selank is more calming. They are sometimes combined for complementary anxiolytic + cognitive enhancement.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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