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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

Semaglutide 10 mg Vial Dosing Protocol

Reconstitution guide, week-by-week titration, and supplies for a 10 mg semaglutide vial.

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Quickstart highlights

Semaglutide is a GLP-1 receptor agonist that enhances insulin secretion and suppresses appetite.

  • Concentration: 6.67 mg/mL (10 mg vial + 1.5 mL bac water).
  • Dose range: 300 µg (Week 1–2) up to 1,000 µg (maintenance) once weekly.
  • At 6.67 mg/mL, 1 unit ≈ 66.7 µg; draw 4.5 units for 300 µg, 15 units for 1,000 µg.
  • A single 10 mg vial yields roughly 10 doses at 1,000 µg maintenance — more cost-effective than a 5 mg vial for longer cycles.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-23004.5Once weeklyStarting dose — draw to 4.5 units on a U-100 syringe
3-46009Once weeklyPause if GI side effects persist
5-6100015Once weeklyMaintenance — at 6.67 mg/mL, 15 units = 1,000 µg

Gradual approach

WeekDose (µg)UnitsNotes
1-42503.75Slower ramp — use a 30-unit syringe, draw to 3.75 units
5-85007.5Increase only if tolerating well
9+100015Maintenance — 15 units on a U-100 syringe

Reconstitution steps

  1. Use 1.5 mL bacteriostatic water; inject slowly down the vial wall to yield 6.67 mg/mL.
  2. Gently swirl until fully dissolved; do not shake.
  3. Label the vial with reconstitution date; refrigerate 2–8 °C.

Supplies needed

8-week plan

  • 1 vial
  • 8 syringes
  • 2 mL bac water
  • 8 alcohol swabs

16-week plan

  • 1 vial
  • 16 syringes
  • 2 mL bac water
  • 16 alcohol swabs

24-week plan

  • 2 vials
  • 24 syringes
  • 4 mL bac water
  • 24 alcohol swabs
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Protocol overview & cycle notes

Support weight management with a GLP-1 agonist titration using a 10 mg compounded vial. Higher concentration means fewer units per dose; a single vial covers 6–10+ weeks at maintenance.

Cycle length: 12 weeks on.

Off-cycle: 8 weeks off between cycles; monitor mood and energy during off-cycle.

Storage & handling

Lyophilized: store in cool, dry place until use. Reconstituted: refrigerate 2–8 °C; use within 28–56 days per manufacturer. Avoid freeze-thaw cycles.

Injection & tracking tips

  • Rotate injection sites (abdomen, thigh, upper arm) to reduce irritation.
  • At 6.67 mg/mL the unit counts are roughly half those of a 5 mg vial — double-check your math before drawing each dose.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • Log injection date, dose (units), and injection site.
  • Track appetite, energy, and any side effects weekly.
Log your cycle in the calculator →

How this works & references

Semaglutide is a GLP-1 receptor agonist that enhances insulin secretion and suppresses appetite. Titration reduces nausea and improves tolerability. Clinical data from the STEP trials support once-weekly dosing for weight management.

Sources

Frequently asked questions

How much bac water do I add to a 10 mg semaglutide vial?
Add 1.5 mL of bacteriostatic water to yield 6.67 mg/mL. Each unit on a U-100 syringe then equals approximately 66.7 µg. Compare: a 5 mg vial at 1.5 mL gives 3.33 mg/mL with 1 unit ≈ 33.3 µg.
How many doses are in a 10 mg vial?
At 6.67 mg/mL, a 10 mg vial reconstituted in 1.5 mL contains roughly 33 doses of 300 µg, or about 10 doses at the 1,000 µg maintenance level — making it more economical for longer cycles.
Is a 10 mg vial better than a 5 mg vial?
A 10 mg vial is more cost-effective for cycles of 10 weeks or more since you draw smaller volumes per dose and the vial lasts longer. A 5 mg vial is useful for a first cycle or if smaller upfront cost is preferred.
What syringes do I use for a 10 mg vial?
Use a U-100 insulin syringe. At 6.67 mg/mL, doses are smaller in volume — a 30-unit U-100 syringe works for most doses through maintenance (15 units = 1,000 µg).

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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