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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

Tirzepatide Dosing Protocol: 30 mg Vial — Week-by-Week Titration & Supplies

Multi-month supply guide for the 30 mg compounded tirzepatide vial — efficient high-volume reconstitution for extended cycles.

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Quickstart highlights

Tirzepatide's dual GIP/GLP-1 receptor agonism produces dose-dependent weight loss.

  • Concentration: 10 mg/mL (30 mg vial + 3 mL bacteriostatic water).
  • At 10 mg/mL: 2.5 mg = 25 units, 5 mg = 50 units, 10 mg = 100 units, 15 mg = 150 units.
  • One 30 mg vial provides: 12 doses at 2.5 mg, 6 at 5 mg, 4 at 7.5 mg, or 3 at 10 mg weekly.
  • Most cost-efficient vial size for patients stabilized on 10–15 mg maintenance dosing.
  • Use within 28 days of reconstitution; refrigerate at 2–8 °C.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-4250025Once weekly2.5 mg — 25 units; one 30 mg vial provides 12 doses at this level
5-8500050Once weekly5 mg — 50 units; one 30 mg vial provides 6 doses
9-12750075Once weekly7.5 mg — 75 units; 4 doses per vial
13-1610000100Once weekly10 mg maintenance — 100 units; 3 doses per vial
17-2012500125Once weekly12.5 mg — 125 units; slightly under 2.5 doses per vial
21+15000150Once weekly15 mg maximum — 150 units; 2 doses per vial

Reconstitution steps

  1. Draw 3 mL bacteriostatic water into a 3 mL syringe; inject slowly down the vial wall to avoid foaming.
  2. Gently swirl for 1–3 minutes until lyophilized cake fully dissolves — do not shake.
  3. Final concentration: 10 mg/mL (30 mg / 3 mL). At this concentration, 1 unit = 100 µg; verify before every dose.
  4. Label with date and concentration (10 mg/mL); refrigerate at 2–8 °C. Use within 28 days.

Supplies needed

12-week plan

  • 1 vial
  • 12 syringes
  • 3 mL bac water
  • 12 alcohol swabs

20-week plan

  • 1 vial
  • 20 syringes
  • 3 mL bac water
  • 20 alcohol swabs

24-week plan

  • 2 vials
  • 24 syringes
  • 6 mL bac water
  • 24 alcohol swabs
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Protocol overview & cycle notes

Provide an extended multi-month supply of tirzepatide from a single high-volume 30 mg vial, reducing reconstitution burden for patients established on 10–15 mg maintenance dosing.

Cycle length: 20 weeks on.

Off-cycle: 8–12 weeks off between cycles.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted: refrigerate at 2–8 °C; use within 28 days. Do not freeze. Note concentration is 10 mg/mL — identical to the 15 mg vial protocol. Always verify concentration label before drawing dose.

Injection & tracking tips

  • The 30 mg vial reconstitutes to 10 mg/mL — same concentration as the 15 mg vial. Syringe unit markings are identical between these two vial sizes.
  • Use a 3 mL syringe for doses of 1 mL or more; a 1 mL U-100 syringe is adequate for doses ≤10 mg (100 units = 1 mL).
  • The 30 mg vial is the most economical option for patients on a stable maintenance dose of 10–15 mg weekly.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • Record body weight and BMI monthly; expect 1–2% body weight loss per month at therapeutic doses.
  • Track waist circumference as a visceral fat proxy — tirzepatide preferentially reduces visceral adiposity.
  • Monitor resting heart rate; tirzepatide can increase HR by 2–4 bpm at maintenance doses.
Log your cycle in the calculator →

How this works & references

Tirzepatide's dual GIP/GLP-1 receptor agonism produces dose-dependent weight loss. Phase 3 SURMOUNT-1 (NCT04184622) demonstrated 20.9% body weight reduction at 15 mg and 19.5% at 10 mg over 72 weeks. SURPASS-CVOT (NCT04255433) data show cardiovascular risk reduction. The 30 mg vial provides up to 3 months of 10 mg maintenance dosing from a single vial, minimizing handling and sterility risk.

Sources

Frequently asked questions

How long does a 30 mg vial last at 10 mg/week?
Exactly 3 weeks — a 30 mg vial reconstituted to 10 mg/mL (3 mL total) provides three 1 mL (10 mg) doses. Always use within 28 days of reconstitution.
Is it safe to draw multiple doses from the same vial over several weeks?
Yes, with proper technique: use bacteriostatic water (not sterile water) to preserve the solution, clean the vial stopper with alcohol before each draw, and refrigerate between uses. Discard after 28 days regardless of remaining volume.
How does the 30 mg vial compare to multiple 5 mg or 10 mg vials?
The 30 mg vial reduces reconstitution events (fewer sterility risks) and is typically more cost-effective per mg. The trade-off is that if the vial is compromised, you lose a larger volume of medication.
Can I use one 30 mg vial for the entire titration phase?
Yes — starting at 2.5 mg, one 30 mg vial provides 12 initial doses, covering weeks 1–12 at the starting dose before titrating up. Plan for additional vials as your dose increases above 2.5 mg.
What is the shelf life of reconstituted tirzepatide?
28 days refrigerated at 2–8 °C when reconstituted with bacteriostatic water. Do not freeze. Inspect for cloudiness or particles before each dose; discard if observed.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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