Tesamorelin Dosage Guide: How Much Should You Take? (2026)

Key Takeaways

• Standard Dosage Range: Typically, Tesamorelin is administered at 2 mg subcutaneously once daily.
• Administration Method: Primarily administered via subcutaneous injection.
• Typical Cycle Length: Treatment cycles often last several months, with periodic evaluation.
• Regulatory Status: Tesamorelin is not FDA-approved for general use; it is available for research purposes only.
• Importance of Medical Supervision: Due to its research-only status, Tesamorelin should be used under the guidance of a healthcare professional.

How Tesamorelin Works in the Body

Tesamorelin, a synthetic analog of growth hormone-releasing hormone (GHRH), functions by binding to the GHRH receptor, thereby stimulating the pituitary gland to release endogenous growth hormone. This mechanism is crucial as it influences the dosage required to achieve desired therapeutic effects. The peptide's pharmacokinetic properties, such as its half-life of approximately 26 to 38 minutes and bioavailability when administered subcutaneously, are critical for determining dosing schedules (PMID 21283099).

Clinical studies have demonstrated Tesamorelin's efficacy in reducing visceral adipose tissue, particularly in patients with HIV-associated lipodystrophy. For instance, a study published in Nature Reviews highlighted its impact on abdominal fat reduction (PMID 21283099).

"In a randomized placebo-controlled trial, Tesamorelin was shown to significantly reduce liver fat and prevent fibrosis progression in HIV-associated NAFLD over one year." (PMID 32701508)

Standard Tesamorelin Dosage Ranges (By Form)

Subcutaneous Injection

• Dosage Range: 2 mg once daily
• Frequency: Administered daily
• Bioavailability: High when injected subcutaneously
• Common Form: Subcutaneous is the most prevalent due to its efficient absorption and ease of use.

While other forms of administration, such as intramuscular or oral, are theoretically possible, subcutaneous injection remains the standard due to its superior bioavailability and patient compliance.

Tesamorelin Dosage by Use Case

HIV-Associated Lipodystrophy

• Typical Dosage Range: 2 mg subcutaneously once daily
• Administration Method: Subcutaneous injection
• Cycle Length: Typically 3 to 6 months, with evaluations
• Clinical Reference: PMID 38905488

Nonalcoholic Fatty Liver Disease (NAFLD) in HIV Patients

• Dosage Range: 2 mg subcutaneously once daily
• Administration Method: Subcutaneous injection
• Cycle Length: 12 months as per clinical trials
• Clinical Reference: PMID 32701508

How Long Should You Take Tesamorelin?

Typical treatment cycles with Tesamorelin range from 3 to 12 months, depending on the therapeutic goals and patient response. Initial effects may be observed within the first few weeks, but significant outcomes often require several months of consistent use. Tapering is not generally required, but ongoing evaluation by a healthcare provider is essential to assess efficacy and safety.

Administration Protocol: How to Take Tesamorelin

Injection Technique

• Needle Gauge: Typically, a 29-31 gauge insulin syringe is used.
• Injection Sites: Rotate between the abdomen, thigh, and upper arm to minimize tissue irritation.
• Rotation Schedule: Change the site with each injection to prevent lipodystrophy.

Storage Requirements

• Temperature: Store at 2-8°C (36-46°F) before reconstitution; after reconstitution, it may be stored at room temperature for a limited time as per manufacturer instructions.
• Light Sensitivity: Keep away from direct light.

Reconstitution Instructions

For detailed reconstitution instructions, refer to our reconstitution guide.

Stacking Tesamorelin for Better Results

Common Stacks

Tesamorelin + Ipamorelin

• Why Combine: Enhances growth hormone release via different mechanisms.
• Dosing Synergy: Tesamorelin at 2 mg daily; Ipamorelin at 200-300 mcg daily.
• Common Protocols: Used in protocols aiming to maximize growth hormone output for body composition improvements.

Tesamorelin + CJC-1295

• Why Combine: Provides a prolonged growth hormone release.
• Dosing Synergy: Tesamorelin at 2 mg daily; CJC-1295 at 1000 mcg weekly.
• Common Protocols: Often used in anti-aging and muscle-building protocols.

Factors That Affect Your Tesamorelin Dosage

Several factors can influence the appropriate dosage of Tesamorelin, including:

• Body Weight: Heavier individuals may require adjustments.
• Age: Older adults may have different sensitivity and metabolic rates.
• Treatment Goals: Specific therapeutic objectives dictate dosing.
• Kidney/Liver Function: Impaired function may necessitate dosage modifications.
• Other Medications: Potential interactions with concurrent medications.

Common Dosing Mistakes to Avoid

• Dosing Too High/Too Low: Always adhere to clinical protocols and adjust under supervision.
• Inconsistent Timing: Maintain a consistent daily schedule for injections.
• Wrong Injection Site: Ensure proper site rotation to avoid local tissue damage.
• Not Accounting for Regulatory Status: Remember Tesamorelin is research-only; use must be supervised.
• Poor Storage/Handling: Incorrect storage can degrade the peptide's efficacy.

What the Evidence Does Not Show

While Tesamorelin has shown promise in specific applications, there are limitations:

• Long-term Safety Data: Comprehensive long-term safety studies are lacking.
• Human Trials: Most data is derived from HIV-associated conditions; applicability to other populations is not well-established.
• Dose-Response Data: Limited data on varying dosages outside standard protocols.

FAQ — Your Top Tesamorelin Dosage Questions Answered

Best Time of Day to Take It

Tesamorelin is best administered at the same time each day, typically in the morning.

What if You Miss a Dose?

If you miss a dose, take it as soon as you remember. If it’s close to the next dose, skip the missed dose.

Can Men and Women Use the Same Dose?

Yes, the standard dosing protocol applies to both men and women.

Can You Stack It with Other Peptides?

Yes, common stacks include Tesamorelin with Ipamorelin or CJC-1295 for synergistic effects.

How Long Until You See Results?

Initial results may be noticed within weeks, but significant changes often require several months.

Do You Need to Cycle Off?

Cycles should be determined by a healthcare provider, but tapering is generally not required.

Is a Loading Dose Needed?

No loading dose is necessary; standard dosing protocols should be followed.

How to Adjust Dose if Side Effects Occur

Consult your healthcare provider to adjust the dose if side effects are experienced.

Conclusion — Finding the Right Dosage for You

Determining the appropriate Tesamorelin dosage involves understanding your specific health goals and working closely with a healthcare provider. While the standard dosage is 2 mg daily, individual factors such as body weight, age, and treatment goals will influence the optimal protocol. Always ensure that any peptide therapy is conducted under professional supervision. For more information, explore our peptide encyclopedia and treatment category pages.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Dosage information is compiled from published research and clinical protocols. Consult a licensed healthcare provider before starting any peptide therapy. Use our clinic finder to locate a qualified provider near you.