Copper Peptides

Overview

Copper peptides are peptide molecules bound to copper ions. They support collagen and elastin production, wound healing, and skin health. The best-characterized member is GHK-Cu (glycyl-L-histidyl-L-lysine–copper), which is on the FDA’s Category 1 list for non-injectable (e.g., topical) use only. Other copper peptide formulations may have different regulatory statuses. In practice, topical copper peptides (creams, serums) are the main legal, compoundable option; injectable GHK-Cu is not on the Category 1 list. People use copper peptides for skin rejuvenation, wound healing, hair growth, and anti-aging. Evidence is moderate for topical applications when used consistently.

How It Works (Mechanism of Action)

Copper is a cofactor for enzymes involved in tissue repair and antioxidant defense. Peptide-copper complexes (e.g., GHK-Cu) deliver copper and peptide motifs to the skin, supporting repair and renewal. Topical application avoids systemic injection and aligns with the compoundable route for GHK-Cu.

Primary Uses

Skin and Anti-Aging

Topical copper peptides are used for fine lines, texture, and rejuvenation. Evidence supports modest benefits with consistent use.