TB-500

Overview

TB-500 is a synthetic version of thymosin beta-4, a naturally occurring peptide involved in cell migration, wound healing, and inflammation. It has been marketed for tissue repair, wound healing, and hair regrowth. Like BPC-157, TB-500 is prohibited for compounding in the US. The FDA places it in Category 2, citing significant safety risks, including potential for immune reactions. It is also a WADA prohibited substance, so athletes subject to anti-doping rules cannot use it. Evidence in humans is limited; much of the data are from animal studies. People interested in legal tissue-support options should consider FDA-approved or legally compoundable alternatives (e.g., topical GHK-Cu where appropriate).

How It Works (Mechanism of Action)

Thymosin beta-4 supports cell migration, angiogenesis, and wound repair in preclinical models. The synthetic form (TB-500) is intended to mimic these effects. Human data are limited.

Primary Uses

Marketed for wound healing, tissue repair, inflammation, and hair regrowth. Evidence is emerging—animal studies, limited human data. Not legal for human use via compounding in the US. WADA prohibited.

FDA & Regulatory Status

Prohibited for compounding. Category 2—FDA cites significant safety risks including potential for immune reactions. Not FDA-approved.