GHK-Cu

Overview

GHK-Cu is a tripeptide-copper complex (glycyl-L-histidyl-L-lysine with copper). It has been studied for skin rejuvenation, wound healing, hair growth, and anti-aging. In the US, GHK-Cu was added to the FDA’s Category 1 list—meaning it can be legally compounded—but only for non-injectable and non-nasal administration. So topical formulations (creams, serums) are within the rules; injectable GHK-Cu is not on the Category 1 list and is not permitted for compounding. Patients and providers must use only the approved routes. Evidence for topical use is moderate, with human studies supporting some skin and wound-healing benefits.

How It Works (Mechanism of Action)

GHK-Cu supports collagen and elastin production, wound repair, and antioxidant activity in the skin. Copper is a cofactor for enzymes involved in tissue repair. Topical application delivers the peptide to the skin without systemic injection.

Primary Uses

Skin Rejuvenation and Anti-Aging

Topical GHK-Cu is used for fine lines, skin texture, and rejuvenation. Evidence from human studies supports modest benefits when used consistently.

Wound Healing and Hair

Some data support a role in wound healing and hair growth. Formulations and evidence vary. Only topical use is compoundable.