MyPeptideMatchOverview
Melanotan II is a synthetic analog of alpha-melanocyte stimulating hormone (alpha-MSH). It has been marketed for tanning, libido enhancement, and fat loss. It is not FDA-approved and has no legal pathway in the US. The FDA and health authorities have raised significant safety concerns: nausea, facial flushing, and potential for melanoma stimulation in susceptible individuals. It is not recommended. It is sometimes compared with PT-141 (Vyleesi) because both act on melanocortin pathways, but PT-141 is FDA-approved for a specific indication (HSDD) and has a defined safety profile; Melanotan II does not. Patients should avoid Melanotan II and use only legal, approved options for tanning or sexual wellness.
How It Works (Mechanism of Action)
Melanotan II activates melanocortin receptors, leading to melanin production (tanning) and effects on libido. The same pathway can carry risks—e.g., theoretical stimulation of melanoma in at-risk individuals. Evidence is emerging with safety concerns documented.
Primary Uses
Marketed for tanning, libido, fat loss. Not approved. Not recommended. Significant safety concerns.
FDA & Regulatory Status
Not FDA-approved. No legal pathway. Significant safety concerns. Not recommended.
