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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

Crystagen Dosing Protocol: 20 mg Vial — Immune System Bioregulator Guide

Crystagen (Lys-Glu-Asp tripeptide) Russian immune system bioregulator dosing guide — thymus function normalization, T-cell activation, and immune aging reversal.

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Quickstart highlights

Crystagen (Lys-Glu-Asp, KED) is a short peptide bioregulator derived from thymus tissue, developed by Khavinson.

  • Concentration: 2 mg/mL. At 2 mg/mL: 200 µg = 10 units daily x 10 days.
  • Target: thymic epithelial cell gene normalization → improved T-cell output.
  • One 20 mg vial = 100 doses; 10 complete 10-day courses from one vial.
  • Pair with Thymosin Alpha-1 for enhanced T-cell activation from two complementary mechanisms.
  • Particularly relevant for immunosenescent individuals aged 50+.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-2 (10-day course)20010Once daily200 µg — 10 units; 10-day intensive course
Maintenance20010Every other day200 µg EOD — immune maintenance

Reconstitution steps

  1. Reconstitute in 2.5 mL bac water portions; inject slowly down vial wall.
  2. Swirl gently until dissolved. Final concentration: 2 mg/mL.
  3. Label with date; refrigerate 2–8 °C. Use within 28 days.

Supplies needed

10_day-week plan

  • 1 vial
  • 10 syringes
  • 2 mL bac water
  • 10 alcohol swabs
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Protocol overview & cycle notes

Normalize thymic T-cell maturation, reduce immunosenescence, and enhance innate and adaptive immunity through the Crystagen tripeptide immune bioregulator 10-day intensive course.

Off-cycle: 4–6 months between intensive courses.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted: refrigerate 2–8 °C; use within 28 days.

Injection & tracking tips

  • Inject subcutaneously at any time of day.
  • Crystagen targets thymus involution reversal — particularly relevant for immunosenescent individuals (>50 years).
  • Combine with Thymosin Alpha-1 for comprehensive T-cell immune augmentation.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • CD4/CD8 T-cell ratio and NK cell activity at baseline and 3 months.
  • Track frequency of infections (respiratory, urinary, etc.) per quarter.
  • Log subjective immune resilience (ability to fight illness) (0–10) monthly.
Log your cycle in the calculator →

How this works & references

Crystagen (Lys-Glu-Asp, KED) is a short peptide bioregulator derived from thymus tissue, developed by Khavinson. The thymus involutes with aging, reducing naive T-cell output and contributing to immunosenescence (the progressive deterioration of immune function with age). Crystagen is proposed to normalize thymic epithelial cell gene expression, potentially restoring thymic output and T-cell repertoire diversity. Russian clinical applications include immunosenescence prevention, recurrent infection management, and post-chemotherapy immune restoration. Khavinson group data shows improved CD3+ and CD4+ T-cell counts after Crystagen courses in aging patients.

Sources

  • Source: Khavinson VK et al. — Immune bioregulators and thymic involution. Ann Gerontol. 2003

Frequently asked questions

How is Crystagen different from Thymosin Alpha-1 for immunity?
Thymosin Alpha-1 is an exogenous thymic hormone that directly activates T-cell, NK cell, and dendritic cell function acutely. Crystagen is a gene expression normalizer that targets thymic epithelial cells — attempting to restore the thymus's capacity to produce T-cells rather than directly activating existing T-cells. Crystagen's action is slower and more structural; TA1's action is more immediate and systemic.
Can Crystagen reverse thymic involution?
Full thymic regeneration (restoration of cortical/medullary architecture) is unlikely from a short peptide bioregulator. Partial restoration of thymic epithelial cell function — improved expression of thymic epithelial-specific genes (FOXN1, DLL4) — is the proposed mechanism. This may increase naive T-cell output marginally rather than restoring a youthful thymus.
Who benefits most from Crystagen?
Based on the immunosenescence targeting: individuals aged 50+ with declining immune function, recurrent infections, or post-cancer immune depletion. Cancer patients post-chemotherapy (with depleted T-cell pools) are another common application in Russian integrative oncology protocols.
Can Crystagen be combined with Epithalon?
Yes — Epithalon (pineal bioregulator/telomerase) + Crystagen (immune/thymic bioregulator) is a complementary combination for comprehensive anti-aging: Epithalon targets cellular longevity mechanisms; Crystagen targets immune system aging. Both use the same 10-day course format and can be alternated (different course periods) or combined in the same course.
Are there contraindications to Crystagen?
Theoretical caution in active autoimmune disease — T-cell augmentation could worsen T-cell-mediated autoimmunity (MS, rheumatoid arthritis, type 1 diabetes). As with all bioregulators, the mechanism is claimed to be normalizing rather than purely stimulating, but clinical evidence in autoimmune populations is absent. Use with specialist guidance in autoimmune conditions.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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