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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

Sermorelin Dosing Protocol: 10 mg Vial — Extended Cycle Dosing & Supplies

Two-month supply guide for sermorelin using the 10 mg vial — efficient for patients on established 300–500 µg nightly protocols.

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Quickstart highlights

Sermorelin GHRH 1-29 NH2 stimulates somatotroph GH release through pituitary GHRH receptor binding.

  • Concentration: 2 mg/mL (10 mg vial + 5 mL bacteriostatic water).
  • At 2 mg/mL: 200 µg = 10 units, 300 µg = 15 units, 500 µg = 25 units nightly.
  • One 10 mg vial provides 33 nightly doses at 300 µg or 20 doses at 500 µg.
  • Inject 30–60 minutes before sleep; avoid food 2 hours prior.
  • Refrigerate; use within 28 days of reconstitution.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-420010Once daily (before bed)200 µg — 10 units nightly; 10 mg vial provides 50 nightly doses at this level
5-1230015Once daily (before bed)300 µg — 15 units; ~33 doses per vial
13+50025Once daily (before bed)500 µg — 25 units; ~20 doses per vial (about 3 weeks of nightly dosing)

Reconstitution steps

  1. Draw 5 mL bacteriostatic water into a 10 mL syringe or in two 2.5 mL draws from a 3 mL syringe.
  2. Inject slowly down the vial wall; swirl gently until fully dissolved — do not shake.
  3. Final concentration: 2 mg/mL. At 2 mg/mL: 1 unit (U-100) = 20 µg.
  4. Label with date and concentration (2 mg/mL); refrigerate at 2–8 °C. Use within 28 days.

Supplies needed

12-week plan

  • 1 vial
  • 84 syringes
  • 5 mL bac water
  • 84 alcohol swabs

24-week plan

  • 2 vials
  • 168 syringes
  • 10 mL bac water
  • 168 alcohol swabs
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Protocol overview & cycle notes

Provide an extended 12-week supply of sermorelin from a single 10 mg vial for patients at established 300–500 µg nightly maintenance dosing, reducing reconstitution frequency versus the 5 mg vial.

Cycle length: 12 weeks on.

Off-cycle: 4–6 weeks off; check IGF-1 before resuming.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted at 2 mg/mL: refrigerate 2–8 °C; use within 28 days. One 10 mg vial provides approximately 33 nights at 300 µg or 20 nights at 500 µg maintenance.

Injection & tracking tips

  • Inject subcutaneously 30–60 minutes before sleep for optimal nocturnal GH pulse amplification.
  • Avoid food for 2 hours before injection; insulinogenic states suppress GH response to sermorelin.
  • The 10 mg vial at 2 mg/mL requires 5 mL bac water — use two separate draws from a 3 mL syringe or a larger syringe if available.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • Measure IGF-1 at baseline and every 6 weeks to track GH axis response.
  • Log morning resting heart rate, sleep hours, and subjective energy (0–10) weekly.
  • Record body composition changes at 8 and 16 weeks.
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How this works & references

Sermorelin GHRH 1-29 NH2 stimulates somatotroph GH release through pituitary GHRH receptor binding. The 10 mg vial provides approximately 33 nightly doses at 300 µg — covering a full 4-week cycle plus buffer — or 20 doses at 500 µg. Physiological GHRH-driven GH secretion preserves hypothalamic feedback control, distinguishing sermorelin from exogenous HGH administration.

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Frequently asked questions

What is the advantage of the 10 mg vial over two 5 mg vials?
The 10 mg vial reduces reconstitution frequency (one reconstitution per ~33 days at 300 µg vs. every ~16 days with a 5 mg vial), lowering sterility risk and handling time. It is also typically more cost-effective per mg.
Does sermorelin work for anti-aging in adults without GH deficiency?
Evidence is limited but suggestive. In GH-sufficient adults over 40, where endogenous GH pulsatility naturally declines, sermorelin can restore GH amplitudes toward younger-adult levels. Walker (2006) and Corpas et al. (1993) document IGF-1 restoration and body composition improvements in older adults.
What IGF-1 target should I aim for?
Most age-management practitioners target IGF-1 in the upper-normal range for chronological age (typically 150–250 ng/mL for adults 40–60). Levels above 350 ng/mL carry increased risk of insulin resistance and potentially cancer promotion; monitor with your prescriber.
Can women use sermorelin?
Yes — sermorelin has been studied and used in women. Female GH release patterns are more frequent and irregular than men's, but GHRH-mediated GH stimulation works similarly. The same dosing protocols apply. Monitor IGF-1 levels to avoid supraphysiological GH states, which carry higher risk in women regarding cancer promotion.
Is sermorelin detectable in drug tests?
Standard athletic or employment drug tests do not screen for sermorelin. WADA does not currently list sermorelin as a prohibited substance (as of 2026), unlike direct GH (HGH). However, indirect GH markers (IGF-1, GH biomarker test) may flag GH use in elite athletics testing.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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