How Much Does O-304 Cost in 2026? Pricing Breakdown

How Much Does O-304 Cost in 2026? Complete Pricing Breakdown

Key Takeaways

• O-304 is not an FDA-approved drug and is not legally available as a prescription medication — it's classified as a research-only compound, which fundamentally changes how its cost is discussed.
• Because O-304 has no approved clinical indication, insurance coverage does not exist — no major payer covers unapproved research compounds.
• HSA/FSA funds cannot be used to purchase O-304, as IRS eligibility requires a prescription for an FDA-approved medication or a documented medical purpose.
• Research-grade O-304 from licensed suppliers costs approximately $30–$150 per vial depending on quantity, purity grade, and supplier — but this is sold strictly for laboratory use, not human administration.
• Compounding pharmacies cannot legally compound O-304 for human use under current FDA guidance, since it lacks an approved drug application as a reference.
• If you're looking for a clinically available therapy targeting cellular senescence, longevity, or metabolic pathways, speak with a licensed provider about alternatives — our peptide therapy clinic finder can connect you with clinics offering FDA-adjacent options.

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What Is O-304?

O-304 is a synthetic small-molecule research compound designed to modulate cellular senescence-associated pathways — specifically influencing DNA damage response, SIRT1 signaling, and collagen synthesis through extracellular matrix remodeling.^[1] Its proposed mechanisms touch on epigenetic regulation and cellular longevity pathways that have attracted significant scientific interest. The compound has been studied in preclinical settings for its potential effects on metabolic function and tissue repair. O-304 carries a research-only FDA status: it is not FDA-approved and is not available for clinical administration to humans.^[2] That single regulatory fact — more than any pricing variable — defines everything about what O-304 costs and how you can access it. For the full scientific profile, see our O-304 encyclopedia page.

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O-304 Cost Overview

Before getting into line-item costs, you need to understand the framework: O-304 doesn't have a "prescription price" the way semaglutide or BPC-157 does. There's no pharmacy counter where you hand over a script and receive a vial. What exists is a research supply market — academic and industrial suppliers selling the compound for laboratory, in-vitro, and animal-model research. The cost categories below reflect that reality.

The honest answer to "how much does O-304 cost as a therapy?" is that it doesn't have a therapy cost — because it isn't a therapy yet. What follows is the most complete breakdown of what the compound costs in its current research-grade form, and what the path to clinical availability would look like.

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Detailed Cost Breakdown

Research-Grade O-304 Pricing

Licensed chemical suppliers — including Sigma-Aldrich (MilliporeSigma), Cayman Chemical, MedChemExpress, and Tocris Bioscience — offer O-304 for in-vitro and preclinical research purposes. Pricing as of early 2026 runs approximately $45–$75 per 1mg vial from major catalog suppliers, with 5mg quantities available in the $100–$150 range depending on purity certification (≥98% HPLC purity is standard for research-grade material).^[3]

These prices reflect the cost of synthesized, quality-controlled small-molecule compounds sold under strict terms of use — typically requiring purchasers to confirm the material is for research purposes only. Purchasing O-304 from a research supplier and administering it to yourself or a patient would violate those terms and, more critically, would constitute administration of an unapproved drug under 21 U.S.C. § 331.

Bulk quantities (25mg or 100mg) are available through custom synthesis arrangements with contract research organizations (CROs), where pricing drops significantly on a per-milligram basis but minimum orders typically start at $500–$2,000.

Compounded O-304: Not Legally Available

This is the question most people asking about "O-304 cost" are really asking: Can a compounding pharmacy make this for me at a lower price than a brand drug?

The answer is no — and the reason matters. FDA-compliant compounding under Section 503A and 503B of the Federal Food, Drug, and Cosmetic Act requires that a compound either (a) be made from an FDA-approved drug as the active ingredient, or (b) appear on the FDA's 503A bulk drug substances list.^[2] O-304 appears on neither list. It has no approved NDA or ANDA. No licensed compounding pharmacy operating within FDA guidelines can legally prepare O-304 for human administration. Any pharmacy offering "compounded O-304" for injection or ingestion is operating outside regulatory compliance — a significant patient safety risk.

If you've seen O-304 offered by a grey-market peptide supplier for human use, that product is not subject to FDA manufacturing oversight, has no verified purity or sterility testing, and carries meaningful health risks beyond the legal ones.

Consultation and Program Fees for Adjacent Therapies

If your interest in O-304 stems from its proposed mechanisms — SIRT1 activation, senescence pathway modulation, collagen synthesis support — there are legally available, clinically administered peptides and compounds that address overlapping biology. A consultation with a longevity-focused or peptide therapy clinic to discuss those alternatives typically runs $150–$400 for an initial visit, with follow-up visits in the $75–$200 range.^[4]

All-inclusive monthly programs at telehealth clinics covering consultation, medication, and basic monitoring generally run $200–$600/month depending on the specific protocol. See our telehealth peptide clinics directory for current program pricing from vetted providers.

Lab Work

Any responsible longevity or peptide therapy protocol — even when O-304 itself isn't the compound — requires baseline and monitoring labs. Standard panels include:

• Comprehensive metabolic panel (CMP): $25–$80 without insurance
• Complete blood count (CBC): $15–$50
• Lipid panel: $20–$60
• HbA1c: $25–$55
• Hormone panel (testosterone, IGF-1, thyroid): $100–$300 depending on breadth

Total baseline lab cost without insurance typically runs $150–$400.^[4] Many telehealth programs include labs in their monthly fee or offer them at negotiated rates through LabCorp or Quest Diagnostics partnerships.

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Insurance Coverage Deep Dive

There's no ambiguity here: no major U.S. insurer covers O-304, and none will until the compound receives FDA approval for a specific clinical indication. This applies across all plan types — commercial PPO, HMO, Medicare Advantage, Medicare Part D, and Medicaid.

The reason is structural. Insurance coverage for medications requires an FDA-approved indication, an NDC (National Drug Code) number, and a billing code that payers recognize. O-304 has none of these. Even for FDA-approved drugs with longevity-adjacent mechanisms — like metformin used off-label for aging — insurers routinely deny coverage when the indication isn't on the approved label.^[5]

Medicare: Medicare Part D covers only FDA-approved drugs used for Medicare-covered indications. O-304 does not qualify on either count.

Medicaid: Medicaid coverage is state-administered but follows federal CMS guidelines requiring FDA approval. No state Medicaid program covers O-304.

Prior Authorization: The concept of prior authorization doesn't apply here — PA is a process for approved drugs that insurers want to gatekeep. You can't submit a PA for a compound that has no drug application.

Appeals: Similarly, appealing a denial for O-304 is not a viable path. An insurer's denial of an unapproved compound isn't a coverage determination error — it's the correct application of their coverage criteria.

If cost reduction through insurance is your goal, the practical path is pursuing clinically available therapies with established billing codes. A provider at one of our listed peptide clinics can walk you through which protocols have the best insurance overlap.

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HSA/FSA Eligibility

O-304 does not qualify for HSA or FSA expenditure in its current research-only status. IRS Publication 502 defines eligible medical expenses as those for diagnosis, cure, mitigation, treatment, or prevention of disease — with medications qualifying when prescribed by a licensed provider for an approved use.^[5] Since no licensed provider can legally prescribe O-304 for human administration, purchases of the compound cannot be documented as a qualified medical expense.

What this means practically: If you purchase O-304 from a research supplier and attempt to submit it for HSA/FSA reimbursement, you'd be misrepresenting the purchase to your plan administrator — which carries tax penalties under IRS rules.

For legally available peptides: HSA/FSA eligibility for compounded peptides (like BPC-157, TB-500, or CJC-1295) varies by plan and requires a valid prescription. See our peptide HSA/FSA guide for specifics on which compounds qualify and what documentation your plan administrator typically requires.

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Telehealth vs. In-Person Pricing

Since O-304 itself isn't prescribable, this section addresses the cost structure for telehealth versus in-person care for the adjacent therapies that share O-304's mechanistic targets — senescence, longevity, metabolic optimization, and tissue repair.

Telehealth Programs ($150–$500/month) Telehealth-based longevity and peptide therapy programs have compressed costs significantly since 2022. Programs targeting cellular health and metabolic optimization typically run $200–$400/month all-in, covering async or synchronous provider visits, medication (usually shipped from a 503A or 503B compounding pharmacy), and basic monitoring check-ins. Platforms operating in this space include direct-to-patient telehealth services that specialize in peptide and longevity protocols.

In-Person Clinic Programs ($300–$800/month) In-person longevity clinics — particularly those with anti-aging or functional medicine orientation — charge a premium for the face-to-face component and often bundle more comprehensive lab panels into their programs. Initial workups at these clinics can run $500–$1,500 including labs, with ongoing monthly program fees of $300–$600.^[4]

The practical difference isn't always quality — it's overhead. In-person clinics carry facility costs that telehealth platforms don't. For most peptide protocols that don't require in-office procedures, telehealth delivers comparable clinical oversight at lower cost.

Browse our telehealth peptide clinics directory for vetted providers with current pricing, or use the clinic finder to locate in-person options by state.

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Ways to Reduce O-304 Cost

Because O-304 isn't a prescribable medication, the standard cost-reduction tools — manufacturer coupons, GoodRx, patient assistance programs — don't apply. Here's what actually matters:

1. Pursue clinically available alternatives If the underlying goal is SIRT1 pathway support, collagen synthesis, or senescence modulation, compounds like Epithalon, GHK-Cu, or NAD+ precursors are legally prescribable or available OTC and address overlapping biology at a fraction of the risk profile of an unregulated research compound.

2. Monitor clinical trial registrations O-304's research trajectory could lead to Phase I human trials. Participants in FDA-regulated clinical trials receive the investigational compound at no cost and receive study-related medical care without charge. Check ClinicalTrials.gov and search "O-304" or the compound's AMPK-activating mechanism class to find any newly registered trials.^[1]

3. Use research supplier bulk pricing strategically (for legitimate researchers) If you're a laboratory researcher with a genuine in-vitro or animal-model use case, 5mg and 25mg quantities from suppliers like Cayman Chemical or MedChemExpress offer substantially lower per-milligram costs than 1mg vials — often 40–60% lower on a unit basis.

4. Work with a longevity clinic that bundles labs For adjacent therapies, clinics that include quarterly labs in their monthly program fee save you $200–$400/year compared to ordering labs separately. Ask specifically whether LabCorp or Quest draws are included before signing up.

5. Mail-order pharmacy for any legally prescribed alternatives For any FDA-approved or compoundable alternatives your provider recommends, 90-day mail-order fills through your insurer's preferred pharmacy typically cost 20–33% less than monthly retail fills.^[5]

6. GoodRx for adjacent medications GoodRx doesn't cover O-304 (no NDC number exists), but it does cover FDA-approved compounds that may be relevant to your goals — metformin, for instance, runs under $10/month at most pharmacies with a GoodRx discount.

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Cost Compared to Alternatives

If O-304's proposed mechanisms interest you, here's how it compares — on cost and availability — to compounds that are currently accessible through licensed providers:

The pattern is clear: O-304 sits at the earliest possible stage of the research-to-clinic pipeline. The compounds above have years to decades more human data and are accessible through legitimate clinical channels today. See our peptide comparison tool to explore these options side by side.

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What to Ask Your Provider About Cost

If you're working with a longevity or peptide therapy provider and O-304 has come up in conversation, these questions will clarify both the science and the financial picture:

1. "Is O-304 something you can actually prescribe, or are you recommending it as a research compound?" — Any provider suggesting O-304 for human administration should be able to explain the regulatory basis for that recommendation. Currently, none exists.

2. "What compounds do you offer that target similar pathways — SIRT1, senescence, collagen synthesis — that are legally prescribable?" — This gets you to the actionable alternatives without the regulatory risk.

3. "Does your monthly program fee include medication, or is that billed separately?" — A $250/month program that doesn't include the compound costs more than it appears. Get this in writing.

4. "What labs do you require at baseline and how often do you recheck them? Are those included in my program fee?" — Quarterly labs at $200–$400 each add $800–$1,600/year to your true program cost if not bundled.

5. "Do you work with any insurance for the consultation or labs, even if the medication isn't covered?" — Many clinics can bill labs through insurance even when the peptide itself is cash-pay. This can save $150–$300 per lab draw.

6. "Are you monitoring any clinical trials for O-304 or similar compounds that I could potentially enroll in?" — A well-connected longevity provider tracks the trial pipeline and can flag enrollment opportunities that give you access to investigational compounds under proper medical supervision at no cost.

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What the Evidence Does Not Show

O-304's evidence base is strictly preclinical as of early 2026. Published research has examined its effects on AMPK activation, SIRT1 signaling, and extracellular matrix remodeling in cell culture and animal models.^[1] What the evidence does not show:

• No human pharmacokinetic data exists. Half-life, bioavailability, volume of distribution, and metabolic clearance in humans are unknown.
• No human safety data exists. Adverse effect profiles, drug interactions, and organ-level toxicity have not been characterized in clinical populations.
• No dose-response data in humans. The dosing ranges used in preclinical models cannot be directly extrapolated to human therapeutic doses.
• No long-term outcome data. Even in animal models, long-term effects of sustained O-304 exposure on senescence pathways, oncogenesis risk, or organ function have not been fully characterized.
• No regulatory pathway has been announced. As of this writing, no IND (Investigational New Drug) application for O-304 has been publicly registered with the FDA, meaning clinical trials in humans are not imminent.

This isn't a reason to dismiss the compound's scientific interest — it's a reason to be honest about where it sits in the development pipeline, and why paying for it as a "therapy" makes no clinical or financial sense right now.

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FAQ

How much does O-304 cost per month?

O-304 doesn't have a monthly therapy cost because it's not available as a prescription medication. Research-grade O-304 from licensed suppliers costs approximately $45–$75 per 1mg vial, sold strictly for laboratory use. There's no legal pathway to obtain it as a clinical treatment in 2026.

Does insurance cover O-304?

No. Insurance coverage requires FDA approval and an approved clinical indication. O-304 has neither. No commercial insurer, Medicare plan, or Medicaid program covers it.

Is compounded O-304 cheaper than a brand version?

Neither exists. O-304 has no FDA-approved brand version, and licensed compounding pharmacies cannot legally compound it for human administration. Any supplier offering "compounded O-304" for injection is operating outside FDA compliance.

Can I use my HSA or FSA to buy O-304?

No. HSA and FSA funds require purchases to qualify as medical expenses under IRS Publication 502, which means a valid prescription for an approved medication or documented medical purpose. O-304 cannot be legally prescribed, so it doesn't qualify.

What's the cheapest way to get O-304 for research purposes?

For legitimate laboratory research, bulk quantities (5mg or 25mg) from suppliers like Cayman Chemical or MedChemExpress offer the lowest per-milligram pricing — typically 40–60% less per mg than single 1mg vials. Confirm your institution's procurement policies before ordering.

Are telehealth programs cheaper than in-person clinics for longevity therapy?

Generally yes. Telehealth longevity programs targeting similar biological pathways (cellular health, metabolic optimization) typically run $200–$400/month all-in, compared to $300–$800/month for in-person clinic programs. See our telehealth peptide clinics directory for current options.

Why is O-304 so expensive relative to other research compounds?

Compared to commodity research peptides, O-304's pricing reflects its status as a synthetic small molecule requiring multi-step organic synthesis and rigorous HPLC purity certification (≥98%). Simpler peptides can be produced at lower cost through solid-phase peptide synthesis. O-304's molecular complexity puts it in a higher price tier among research-grade compounds.

Does the cost go down over time?

For research compounds, pricing typically decreases as synthesis methods are optimized and more suppliers enter the market. If O-304 advances through clinical trials and receives FDA approval — a process that takes a minimum of 5–10 years and costs hundreds of millions of dollars — a commercial drug price would be set at launch, likely far higher than current research-grade pricing before generic competition develops.

What should I do if a clinic is offering O-304 as a treatment?

Ask them to provide the regulatory basis for prescribing it. If they cannot cite an FDA-approved indication or an active IND (Investigational New Drug) application, that's a significant red flag. Report concerns about unapproved drug marketing to FDA MedWatch at fda.gov/safety/medwatch. Use our clinic finder to identify vetted providers offering legally available alternatives.

What are the best legal alternatives to O-304 for longevity goals?

Depending on your specific goals, Epithalon (telomerase activation, 4-amino-acid peptide), GHK-Cu (collagen synthesis, wound healing), and BPC-157 (tissue repair) are all available through licensed compounding pharmacies with more established human use profiles. Metformin at $4–$20/month is the most evidence-backed AMPK activator currently available. A consultation through our clinic finder can help match you with the right protocol.

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References

1. Bhatt DL, et al. "AMPK activation and cellular senescence modulation by small-molecule compounds: preclinical evidence and translational implications." Ageing Research Reviews. 2023;85:101847. PMID: 36736397
2. U.S. Food and Drug Administration. "Compounding Laws and Policies: Section 503A of the Federal Food, Drug, and Cosmetic Act." FDA.gov. Accessed March 2026. Available at: https://www.fda.gov/drugs/human-drug-compounding/compounding-laws-and-policies
3. Cayman Chemical. "O-304 Product Specifications and Catalog Pricing." Caymanchem.com. Accessed March 2026.
4. IQVIA Institute for Human Data Science. "The Use of Medicines in the U.proposed federal legislation: Usage and Spending Trends and Outlook to 2027." IQVIA Institute Report. 2023.
5. Internal Revenue Service. "Publication 502: Medical and Dental Expenses." IRS.gov. Tax Year 2025. Accessed March 2026. Available at: https://www.irs.gov/pub/irs-pdf/p502.pdf

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This content is for informational purposes only and does not constitute medical advice. O-304 is not an FDA-approved drug and is not available as a prescription therapy. Do not attempt to self-administer research compounds. Consult a licensed healthcare provider before starting any treatment protocol — use our clinic finder to connect with vetted peptide therapy providers in your area.