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Reviewed by MyPeptideMatch Editorial TeamLast reviewed February 2026Updated February 2026

GHRP-6 Dosing Protocol: 2 mg Vial — Starter Dosing Guide & Supplies

GHRP-6 starter protocol using the compact 2 mg vial — appropriate for testing sensitivity before progressing to larger vials.

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Quickstart highlights

GHRP-6 is a hexapeptide ghrelin receptor agonist with the strongest appetite-stimulating properties among commonly used GHRPs, due to its partial gastric motility effects in addition to central ghrelin receptor binding.

  • Concentration: 2 mg/mL (2 mg vial + 1 mL bacteriostatic water).
  • At 2 mg/mL: 100 µg = 5 units, 200 µg = 10 units.
  • 2 mg vial provides 20 doses at 100 µg — ideal starter size to assess hunger tolerance.
  • GHRP-6 causes significant appetite stimulation within 30 minutes; plan meals accordingly.
  • Refrigerate; use within 28 days.

Dosing table

For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.

WeekDose (µg)UnitsFrequencyNotes
1-210051–2x daily (fasted)100 µg — 5 units; 2 mg vial provides 20 doses at this level; test hunger response
3-4200101–3x daily (fasted)200 µg — 10 units; 10 doses per vial; move to 5 mg vial for continued use

Reconstitution steps

  1. Draw 1 mL bacteriostatic water; inject slowly down the vial wall.
  2. Swirl gently until powder dissolves; do not shake.
  3. Final concentration: 2 mg/mL. At 2 mg/mL: 1 unit = 20 µg.
  4. Label with date; refrigerate at 2–8 °C. Use within 28 days.

Supplies needed

4-week plan

  • 2 vials
  • 28 syringes
  • 2 mL bac water
  • 28 alcohol swabs
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Protocol overview & cycle notes

Assess GHRP-6 GH secretagogue response and hunger tolerance using the compact 2 mg starter vial before committing to a full 5 mg or 10 mg vial cycle.

Cycle length: 4 weeks on.

Off-cycle: 2–4 weeks off after 4-week starter cycle; progress to 5 mg vial for full protocol.

Storage & handling

Lyophilized: store below 25 °C. Reconstituted at 2 mg/mL: refrigerate 2–8 °C; use within 28 days. The 2 mg vial is a trial size — plan to transition to 5 mg or 10 mg vials for extended cycles.

Injection & tracking tips

  • GHRP-6 causes significant hunger within 20–30 minutes post-injection; plan injections immediately before a planned meal if appetite stimulation is desired.
  • The 2 mg vial is recommended for first-time GHRP-6 users to assess hunger sensitivity before committing to larger supplies.
  • Inject subcutaneously in the abdomen, 2 inches from the navel.

Tracking

Logging helps you and your provider spot patterns and adjust dose or timing.

  • Track hunger level (0–10) for 60 minutes post-injection to assess ghrelin-mediated appetite response.
  • Weigh yourself daily for the first week to monitor water retention from GH elevation.
  • Log sleep quality nightly if injecting at bedtime.
Log your cycle in the calculator →

How this works & references

GHRP-6 is a hexapeptide ghrelin receptor agonist with the strongest appetite-stimulating properties among commonly used GHRPs, due to its partial gastric motility effects in addition to central ghrelin receptor binding. GH pulse amplitudes are comparable to GHRP-2 at equivalent doses, but pronounced hunger (reported by ~80% of users) distinguishes it from ipamorelin and GHRP-2.

Sources

Frequently asked questions

Why is GHRP-6 known for causing extreme hunger?
GHRP-6 activates ghrelin receptors in the hypothalamic NPY/AgRP neurons and also affects gastric motility via vagal ghrelin pathways. The hunger response peaks 20–30 minutes post-injection and subsides within 60–90 minutes. This can be used therapeutically in underweight or anorexic patients.
Is the 2 mg vial cost-effective?
The 2 mg vial is only recommended for initial tolerance testing. At 200 µg 2x daily, a 2 mg vial lasts 5 days — insufficient for even a 1-week trial. Transition to the 5 mg or 10 mg vial for practical use.
Can GHRP-6 be used for appetite stimulation in medical settings?
GHRP-6 has been studied for cachexia (cancer, AIDS wasting, anorexia). Its ghrelin-mimetic appetite stimulation is more pronounced than GHRP-2 or ipamorelin. Formal clinical approval for this indication does not exist in the US, but research use in compounding protocols exists.
How does GHRP-6 affect cortisol compared to GHRP-2?
GHRP-6 produces cortisol and prolactin elevation comparable to GHRP-2 at equivalent doses (approximately 20–40% above baseline at 200 µg). Neither is cortisol-neutral; ipamorelin remains the preferred choice when cortisol elevation is a concern.
Should I move to a larger vial after the 2 mg trial?
Yes — if GHRP-6 is well-tolerated after the 2 mg trial (acceptable hunger response, no significant GI distress), the 5 mg vial (25 doses at 200 µg) or 10 mg vial (50 doses at 200 µg) is appropriate for a full 4–12 week cycle.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.

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