MyPeptideMatchIpamorelin Dosing Protocol: 5 mg Vial — Daily Dosing Schedule & Supplies
Week-by-week ipamorelin dosing guide using the 5 mg vial — the cleanest GHRP for precise, cortisol-free growth hormone stimulation.
Quickstart highlights
Ipamorelin (Ala-His-D-2-Nal-D-Phe-Lys-NH2) is a pentapeptide ghrelin receptor agonist (GHSR-1a) that selectively stimulates GH release without activating ACTH/cortisol or prolactin axes — distinguishing it from GHRP-2 and GHRP-6.
- Concentration: 2 mg/mL (5 mg vial + 2.5 mL bacteriostatic water).
- At 2 mg/mL: 200 µg = 10 units, 300 µg = 15 units.
- Ipamorelin does not elevate cortisol or prolactin — the most selective GHRP available.
- Combine with CJC-1295 or sermorelin for 2–4x greater GH secretion versus ipamorelin alone.
- Inject in fasted state (2+ hours post-meal); food-driven insulin blunts GH response.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
| Week | Dose (µg) | Units | Frequency | Notes |
|---|---|---|---|---|
| 1-4 | 200 | 10 | Once daily (before bed) | 200 µg — 10 units; single nightly injection; one vial provides 25 doses |
| 5-12 | 300 | 15 | Once or twice daily | 300 µg — 15 units; add morning injection for enhanced GH pulsatility if desired |
| 13+ | 300 | 15 | 2–3x daily | 300 µg 2–3x daily for maximum GH secretion; space 4+ hours between doses |
Reconstitution steps
- Draw 2.5 mL bacteriostatic water; inject slowly down the vial wall.
- Swirl gently until powder fully dissolves; do not shake.
- Final concentration: 2 mg/mL (2,000 µg/mL). At this concentration: 200 µg = 10 units, 300 µg = 15 units.
- Label with date; refrigerate at 2–8 °C. Use within 28 days.
Supplies needed
4-week plan
- 1 vial
- 28 syringes
- 3 mL bac water
- 28 alcohol swabs
8-week plan
- 2 vials
- 56 syringes
- 5 mL bac water
- 56 alcohol swabs
12-week plan
- 2 vials
- 84 syringes
- 5 mL bac water
- 84 alcohol swabs
Protocol overview & cycle notes
Stimulate clean, pulsatile GH release through ghrelin receptor agonism with ipamorelin — the most selective GHRP available, producing meaningful GH secretion without cortisol, prolactin, or significant cortisol elevation.
Cycle length: 12 weeks on.
Off-cycle: 4 weeks off after every 12-week cycle.
Storage & handling
Injection & tracking tips
- Inject subcutaneously in fasted state or 2 hours post-meal; insulin elevation suppresses GH response to ipamorelin.
- Ipamorelin does not elevate cortisol or prolactin — a key advantage over GHRP-2 and GHRP-6 at equivalent doses.
- When combining with CJC-1295 or sermorelin, inject both peptides simultaneously or within 5 minutes — GHRH + GHRP synergy is immediate.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
- Measure IGF-1 at baseline and 6 weeks; ipamorelin typically raises IGF-1 by 30–50 ng/mL per 12-week cycle.
- Track sleep quality nightly (wearable deep sleep data or subjective 0–10 scale).
- Monitor fasting glucose monthly — GH elevation can transiently increase glucose at higher doses.
How this works & references
Sources
- Ipamorelin, the first selective growth hormone secretagogue. Raun K et al. — Eur J Endocrinol — 1998
- Source: Bowers CY — Unnatural growth hormone-releasing peptide begets natural ghrelin. J Clin Endocrinol Metab. 2001
- Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Gobburu JV et al. — Pharm Res — 1999
- Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Beck DE et al. — Int J Colorectal Dis — 2014
Frequently asked questions
How does ipamorelin compare to GHRP-2 and GHRP-6?
Can I take ipamorelin 3x daily?
Does ipamorelin cause water retention?
Is ipamorelin WADA-prohibited?
When will I notice results from ipamorelin + CJC-1295?
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View protocolThis content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.