CJC-1295 Dosage Guide: How Much Should You Take? (2026)

Key Takeaways

• Standard Dosage Range: CJC-1295 is typically administered at doses ranging from 100 to 300 mcg per injection, depending on the therapeutic goal.
• Administration Method: The most common route is subcutaneous injection, known for its higher bioavailability compared to other forms.
• Typical Cycle Length: Treatment cycles often last between 8 to 12 weeks, with adjustments based on individual response and goals.
• Regulatory Status: CJC-1295 is not FDA-approved for clinical use and is primarily available for research purposes.
• Medical Supervision: It is crucial to consult with a healthcare provider to determine the appropriate dosage and monitor for side effects.

How CJC-1295 Works in the Body

CJC-1295 is a growth hormone-releasing hormone (GHRH) analog that stimulates the release of growth hormone (GH) from the pituitary gland. Its mechanism of action involves binding to the GHRH receptor, initiating a cascade that results in increased GH and insulin-like growth factor 1 (IGF-1) levels. This peptide is unique due to its extended half-life, achieved by covalent binding to serum albumin, which prolongs its activity in the bloodstream.

The pharmacokinetics of CJC-1295, including its receptor binding affinity and bioavailability, play a critical role in determining the appropriate dosage. According to a study published in The Journal of Clinical Endocrinology and Metabolism, CJC-1295 has been shown to stimulate GH and IGF-1 secretion for more than six days after a single administration (PMID 16352683). This prolonged action reduces the need for frequent dosing compared to other GHRH analogs.

"CJC-1295's ability to covalently bind plasma proteins extends its half-life significantly, allowing for less frequent dosing while maintaining efficacy" (PMID 30938069).

Standard CJC-1295 Dosage Ranges (By Form)

Subcutaneous Injection

• Dosage Range: 100 to 300 mcg per injection
• Frequency: Typically administered 1 to 3 times per week
• Bioavailability: High, due to direct absorption into the bloodstream
• Commonality: The preferred method due to its effectiveness and ease of administration

Intramuscular Injection

• Dosage Range: Similar to subcutaneous, though less commonly used
• Frequency: 1 to 3 times per week
• Bioavailability: Comparable to subcutaneous, but with potentially more discomfort

Comparison

Subcutaneous injections are generally favored for their convenience and lower discomfort levels compared to intramuscular injections. The bioavailability of both forms is high, but subcutaneous injections offer a more user-friendly experience.

CJC-1295 Dosage by Use Case

Growth Hormone Deficiency

• Typical Dosage Range: 100 to 200 mcg per injection
• Administration Method: Subcutaneous injection
• Cycle Length: 8 to 12 weeks
• Clinical Reference: Many clinics follow protocols similar to those outlined in studies like PMID 16352683, which demonstrate efficacy in increasing GH levels in deficient individuals.

Anti-Aging

• Typical Dosage Range: 100 to 150 mcg per injection
• Administration Method: Subcutaneous injection
• Cycle Length: 12 weeks or longer, depending on individual goals
• Guidance: Clinics often prescribe lower doses for anti-aging to minimize potential side effects while still achieving benefits.

Body Composition Improvement

• Typical Dosage Range: 150 to 300 mcg per injection
• Administration Method: Subcutaneous injection
• Cycle Length: 8 to 10 weeks
• Clinical Reference: Protocols often mirror those used in studies focusing on body composition changes, with adjustments based on individual progress and side effects.

How Long Should You Take CJC-1295?

The duration of CJC-1295 therapy varies based on the treatment goal and individual response. Typical cycles last between 8 to 12 weeks. During the first week, patients might notice subtle changes, while more significant results often appear between weeks 2 and 4. By week 6, most individuals report noticeable improvements in their targeted areas.

Tapering off is generally not required due to CJC-1295's prolonged half-life and sustained action. However, it is essential to monitor for any adverse effects and adjust the cycle length accordingly. Discontinuation generally leads to a gradual return to baseline GH levels.

Administration Protocol: How to Take CJC-1295

Injection Technique

• Needle Gauge: Use a 29 to 31-gauge insulin syringe for comfort.
• Injection Sites: Rotate between the abdomen, thigh, and upper arm to prevent tissue irritation.
• Rotation Schedule: Change sites with each injection to allow healing.

Storage Requirements

• Temperature: Store lyophilized powder in a refrigerator at 2-8°C (36-46°F).
• Light Sensitivity: Protect from light to maintain stability.
• Reconstituted Stability: Use within 14 days of reconstitution.

Reconstitution Instructions

• Step-by-step Process: Refer to our reconstitution guide for detailed instructions.

Stacking CJC-1295 for Better Results

CJC-1295 and Ipamorelin

• Combination Rationale: Both peptides synergistically increase GH release.
• Dosing Synergy: CJC-1295 at 100-200 mcg combined with Ipamorelin at 100-200 mcg per injection.
• Common Protocols: Often used in anti-aging and body composition protocols for enhanced effects.

CJC-1295 and GHRP-6

• Combination Rationale: Enhances GH release through different mechanisms.
• Dosing Synergy: CJC-1295 at 100-200 mcg with GHRP-6 at 100-200 mcg.
• Named Protocols: Frequently referenced in the "Wolverine protocol" for recovery and muscle growth.

Factors That Affect Your CJC-1295 Dosage

Several factors influence the appropriate dosage of CJC-1295, including body weight, age, treatment goals, and individual response. Providers often adjust dosing based on these variables to optimize outcomes while minimizing side effects. Kidney and liver function also play a role, as impaired function may alter peptide metabolism and clearance.

Common Dosing Mistakes to Avoid

• Dosing Too High/Too Low: Can lead to suboptimal results or increased side effects.
• Inconsistent Timing: Reduces the efficacy of the therapy.
• Wrong Injection Site for the Goal: May affect absorption and effectiveness.
• Not Accounting for Regulatory Status: Using non-approved peptides without medical supervision can be risky.
• Poor Storage/Handling: Compromises peptide stability and efficacy.

What the Evidence Does Not Show

While CJC-1295 shows promise in various therapeutic areas, there are limitations to the existing evidence. Long-term safety data is lacking, and most studies are short-term or conducted in animals. Human trials are limited, and dose-response data is not fully established. These gaps highlight the need for ongoing research to validate the peptide's efficacy and safety.

FAQ — Your Top CJC-1295 Dosage Questions Answered

Best time of day to take it?

CJC-1295 can be administered at any time, but many prefer evening injections to align with natural GH release cycles.

What if you miss a dose?

If a dose is missed, take it as soon as possible unless it's close to the next scheduled dose. Do not double up.

Can men and women use the same dose?

Generally, yes, but individual factors like body weight and goals may necessitate adjustments.

Can you stack it with other peptides?

Yes, CJC-1295 is often stacked with peptides like Ipamorelin for synergistic effects.

How long until you see results?

Results vary, but many report noticeable changes within 4 to 6 weeks.

Do you need to cycle off?

While not always necessary, cycling off can help assess natural GH levels and reset receptors.

Is a loading dose needed?

No loading dose is typically required due to CJC-1295's long half-life.

How to adjust dose if side effects occur?

Consult with a healthcare provider to adjust the dose or frequency if side effects are experienced.

Conclusion — Finding the Right Dosage for You

Determining the optimal CJC-1295 dosage involves careful consideration of individual goals, response, and medical supervision. Standard dosing ranges typically fall between 100 to 300 mcg per injection, administered subcutaneously. Always consult with a healthcare provider to tailor the dosage to your specific needs and ensure safe and effective use. For more information on peptide therapy and to find a qualified provider, explore our clinic finder and related peptide pages.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Dosage information is compiled from published research and clinical protocols. Consult a licensed healthcare provider before starting any peptide therapy. Use our clinic finder to locate a qualified provider near you.