Overview
Dihexa is a synthetic hexapeptide (angiotensin IV analog) studied for cognitive enhancement, neurogenesis, and Alzheimer’s research. It is not FDA-approved and is research only in the US. Evidence is emerging, with primarily animal studies (including work at the University of Washington). There is very limited human safety data—a key concern for anyone considering use outside of a formal research setting. It is not a legal prescription or compounded option for general use in the US. Patients interested in cognitive support should consider evidence-based, legal options and discuss participation in clinical trials if appropriate.
How It Works (Mechanism of Action)
Dihexa is an angiotensin IV analog that may support neurogenesis and cognitive function in preclinical models. Mechanisms in humans are not established.
Primary Uses
Cognitive enhancement, neurogenesis, Alzheimer’s research. Research only. Very limited human safety data.
FDA & Regulatory Status
Not FDA-approved. Research only. Very limited human safety data.
Last reviewed February 2026.
Clinical Evidence
Emerging—primarily animal studies. Very limited human data.
Side Effects & Safety
Very limited human safety data. Use outside research is not recommended.
