Evoke Health and Wellness

Evoke Health and Wellness operates as a telehealth-focused functional medicine practice serving patients throughout Missouri from its Springfield base, led by nurse practitioner Samantha Neville, NP-C. Neville holds certifications from both the American Academy for Anti-Aging and Medicine (A4M) and the American Society for Reproductive Medicine (ASRM), bringing specialized training in age management and reproductive health to her clinical approach. The practice structures its services around virtual consultations, allowing patients across Missouri to access hormone optimization and metabolic health support without geographic limitations.

The clinic's treatment protocols center on GLP-1 receptor agonist peptides for metabolic intervention, specifically offering tirzepatide and semaglutide as pharmaceutical-grade options for weight management. Tirzepatide functions as a dual GIP/GLP-1 receptor agonist, while semaglutide operates as a selective GLP-1 agonist—both prescribed within comprehensive programs that include metabolic assessment, dosing titration schedules, and ongoing monitoring for side effect management. These peptide therapies address insulin sensitivity, appetite regulation, and body composition changes in patients with metabolic dysfunction or obesity-related health concerns. The practice integrates these medications with nutritional guidance and laboratory monitoring rather than prescribing them as standalone interventions.

Samantha Neville's clinical focus encompasses hormone replacement therapy for perimenopausal and postmenopausal women, including patients who have undergone hysterectomy and require tailored hormone protocols. Her ASRM certification informs her approach to reproductive hormone transitions, while her A4M training shapes her methodology for bioidentical hormone replacement and age-related hormonal decline. The practice addresses thyroid dysfunction, adrenal health, and sex hormone imbalances through laboratory assessment and individualized replacement strategies. Neville's functional medicine framework examines underlying causes of hormonal disruption rather than solely managing symptoms, incorporating evaluation of gut health, nutrient deficiencies, and metabolic markers that influence endocrine function.

Patients begin with a telehealth intake consultation where Neville reviews medical history, current symptoms, and treatment goals, followed by laboratory requisitions for hormone panels, metabolic markers, and nutritional assessments as clinically indicated. Follow-up visits occur via secure video platform, with medication adjustments and supplement recommendations made based on patient response and repeat laboratory values. The practice provides direct access to Neville between scheduled appointments for questions about medication tolerance, side effects, or protocol adjustments. For patients initiating tirzepatide or semaglutide, the clinic establishes baseline metabolic parameters and implements gradual dose escalation protocols to minimize gastrointestinal side effects while optimizing therapeutic response.

Evoke Health and Wellness differentiates itself through Neville's dual specialization in reproductive endocrinology and anti-aging medicine, allowing the practice to address complex cases involving metabolic syndrome in perimenopausal women or weight management challenges complicated by hormonal imbalances. The telehealth delivery model eliminates travel requirements for Springfield-area patients and extends access to rural Missouri communities with limited functional medicine resources. The practice maintains a supplement dispensary for pharmaceutical-grade nutritional products that support hormone metabolism, blood sugar regulation, and metabolic health, selected based on third-party testing and bioavailability standards. This combination of peptide therapy expertise, hormone specialization, and virtual accessibility positions the clinic as a resource for Missouri patients seeking integrated approaches to metabolic and endocrine health concerns.